http://purl.uniprot.org/citations/21525190 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/21525190 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of this study was to evaluate HDPR1 expression in esophageal squamous cell carcinoma (ESCC) and the relationship between HDPR1 and beta-catenin by immunohistochemical analysis. The clinical relevance of these proteins was also analyzed. Immunohistochemistry was performed on paraffin-embedded tissue specimens from 184 ESCC patients to detect the expression of HDPR1 and beta-catenin. The correlation between the results of immunoexpression and the clinicopathologic features was processed statistically. Increased cytoplasmic and nuclear HDPR1 expression was noted in 100 (54.3%) and 131 (71.2%) of 184 specimens, respectively. Statistical analysis showed significant associations of cytoplasmic HDPR1 with regional lymph node metastasis (p = 0.021) and P-stage (p = 0.004). The increased nuclear staining was only correlated with P-stage (p = 0.047). Significant associations of coexpression of cytoplasmic and nuclear HDPR1 with regional lymph node metastasis (p = 0.015) or P-stage (p = 0.002) were observed. Enhanced cytoplasmic expression of HDPR1 was positively correlated with increased cytoplasmic but not reduced membranous beta-catenin expression (r = 0.239, p = 0.027 and r = 0.126, p = 0.089, respectively). These finding suggested that cytoplasmic HDPR1 protein expression was associated with tumor malignant progression via beta-catenin accumulation. It implicated that cytoplasmic HDPR1 expression may serve as a potential predictive factor for lymph node metastasis and tumor development in ESCC."xsd:string |
http://purl.uniprot.org/citations/21525190 | http://purl.org/dc/terms/identifier | "doi:10.1369/0022155411409941"xsd:string |
http://purl.uniprot.org/citations/21525190 | http://purl.uniprot.org/core/author | "Shen J."xsd:string |
http://purl.uniprot.org/citations/21525190 | http://purl.uniprot.org/core/author | "Hou J."xsd:string |
http://purl.uniprot.org/citations/21525190 | http://purl.uniprot.org/core/author | "Xu L.Y."xsd:string |
http://purl.uniprot.org/citations/21525190 | http://purl.uniprot.org/core/author | "Wu J.Y."xsd:string |
http://purl.uniprot.org/citations/21525190 | http://purl.uniprot.org/core/author | "Wu Z.Y."xsd:string |
http://purl.uniprot.org/citations/21525190 | http://purl.uniprot.org/core/author | "Guo M.Z."xsd:string |
http://purl.uniprot.org/citations/21525190 | http://purl.uniprot.org/core/author | "Li E.M."xsd:string |
http://purl.uniprot.org/citations/21525190 | http://purl.uniprot.org/core/author | "Shen J.H."xsd:string |
http://purl.uniprot.org/citations/21525190 | http://purl.uniprot.org/core/author | "Xu X.E."xsd:string |
http://purl.uniprot.org/citations/21525190 | http://purl.uniprot.org/core/author | "Qiao-Huang"xsd:string |
http://purl.uniprot.org/citations/21525190 | http://purl.uniprot.org/core/author | "Qing-Zhao"xsd:string |
http://purl.uniprot.org/citations/21525190 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
http://purl.uniprot.org/citations/21525190 | http://purl.uniprot.org/core/name | "J Histochem Cytochem"xsd:string |
http://purl.uniprot.org/citations/21525190 | http://purl.uniprot.org/core/pages | "711-718"xsd:string |
http://purl.uniprot.org/citations/21525190 | http://purl.uniprot.org/core/title | "Cytoplasmic HDPR1 is involved in regional lymph node metastasis and tumor development via beta-catenin accumulation in esophageal squamous cell carcinoma."xsd:string |
http://purl.uniprot.org/citations/21525190 | http://purl.uniprot.org/core/volume | "59"xsd:string |
http://purl.uniprot.org/citations/21525190 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21525190 |
http://purl.uniprot.org/citations/21525190 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21525190 |
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http://purl.uniprot.org/uniprot/#_B7Z673-mappedCitation-21525190 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21525190 |
http://purl.uniprot.org/uniprot/#_B7ZAV8-mappedCitation-21525190 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21525190 |
http://purl.uniprot.org/uniprot/#_Q5DM88-mappedCitation-21525190 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21525190 |