| http://purl.uniprot.org/citations/21525388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21525388 | http://www.w3.org/2000/01/rdf-schema#comment | "CD103(+) dendritic cells (DCs) are the major conventional DC population in the intestinal lamina propria (LP). Our previous report showed that a small number of cells in the LP could be classified into four subsets based on the difference in CD11c/CD11b expression patterns: CD11c(hi)CD11b(lo) DCs, CD11c(hi)CD11b(hi) DCs, CD11c(int)CD11b(int) macrophages, and CD11c(int)CD11b(hi) eosinophils. The CD11c(hi)CD11b(hi) DCs, which are CD103(+), specifically express TLR5 and induce the differentiation of naive B cells into IgA(+) plasma cells. These DCs also mediate the differentiation of Ag-specific Th17 and Th1 cells in response to flagellin. We found that small intestine CD103(+) DCs of the LP (LPDCs) could be divided into a small subset of CD8α(+) cells and a larger subset of CD8α(-) cells. Flow cytometry analysis revealed that CD103(+)CD8α(+) and CD103(+)CD8α(-) LPDCs were equivalent to CD11c(hi)CD11b(lo) and CD11c(hi)CD11b(hi) subsets, respectively. We analyzed a novel subset of CD8α(+) LPDCs to elucidate their immunological function. CD103(+)CD8α(+) LPDCs expressed TLR3, TLR7, and TLR9 and produced IL-6 and IL-12p40, but not TNF-α, IL-10, or IL-23, following TLR ligand stimulation. CD103(+)CD8α(+) LPDCs did not express the gene encoding retinoic acid-converting enzyme Raldh2 and were not involved in T cell-independent IgA synthesis or Foxp3(+) regulatory T cell induction. Furthermore, CD103(+)CD8α(+) LPDCs induced Ag-specific IgG in serum, a Th1 response, and CTL activity in vivo. Accordingly, CD103(+)CD8α(+) LPDCs exhibit a different function from CD103(+)CD8α(-) LPDCs in active immunity. This is the first analysis, to our knowledge, of CD8α(+) DCs in the LP of the small intestine."xsd:string |
| http://purl.uniprot.org/citations/21525388 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1004036"xsd:string |
| http://purl.uniprot.org/citations/21525388 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/21525388 | http://purl.uniprot.org/core/author | "Fujimoto K."xsd:string |
| http://purl.uniprot.org/citations/21525388 | http://purl.uniprot.org/core/author | "Machida T."xsd:string |
| http://purl.uniprot.org/citations/21525388 | http://purl.uniprot.org/core/author | "Ishii K.J."xsd:string |
| http://purl.uniprot.org/citations/21525388 | http://purl.uniprot.org/core/author | "Aoshi T."xsd:string |
| http://purl.uniprot.org/citations/21525388 | http://purl.uniprot.org/core/author | "Uematsu S."xsd:string |
| http://purl.uniprot.org/citations/21525388 | http://purl.uniprot.org/core/author | "Takemura N."xsd:string |
| http://purl.uniprot.org/citations/21525388 | http://purl.uniprot.org/core/author | "Haseda Y."xsd:string |
| http://purl.uniprot.org/citations/21525388 | http://purl.uniprot.org/core/author | "Karuppuchamy T."xsd:string |
| http://purl.uniprot.org/citations/21525388 | http://purl.uniprot.org/core/author | "Shimohigoshi M."xsd:string |
| http://purl.uniprot.org/citations/21525388 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21525388 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21525388 | http://purl.uniprot.org/core/pages | "6287-6295"xsd:string |
| http://purl.uniprot.org/citations/21525388 | http://purl.uniprot.org/core/title | "A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity."xsd:string |
| http://purl.uniprot.org/citations/21525388 | http://purl.uniprot.org/core/volume | "186"xsd:string |
| http://purl.uniprot.org/citations/21525388 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21525388 |
| http://purl.uniprot.org/citations/21525388 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21525388 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GTA2-mappedCitation-21525388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21525388 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VI41-mappedCitation-21525388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21525388 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GS40-mappedCitation-21525388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21525388 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GSY9-mappedCitation-21525388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21525388 |
| http://purl.uniprot.org/uniprot/#_B2RWT2-mappedCitation-21525388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21525388 |