| http://purl.uniprot.org/citations/21525884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21525884 | http://www.w3.org/2000/01/rdf-schema#comment | "Dendritic cell (DC)-derived IL-1α/β plays a critical role in the induction of T helper type 1 (Th1)-dependent immunity against Leishmania. DCs from susceptible BALB/c mice produce less IL-1α/β when compared with resistant C57BL/6 mice, contributing to aberrant Th2 development and ultimate death of infected mice. We have extended our studies of the role of IL-1 in leishmaniasis using IL-1RA(-/-) BALB/c mice that are characterized by upregulated IL-1 receptor signaling. Unexpectedly, infection of IL-1RA(-/-) mice led to significantly worsened disease outcome with larger lesions, dramatically higher parasite burdens, and decreased IFN-γ production by antigen-specific T cells. We determined that IL-1RA(-/-) DCs were more mature already in the steady state, exhibited less phagocytotic capacity, and IL-12 production in response to various stimuli was impaired. Our data suggest that in addition to effects on Th education, IL-1α/β signaling also modulates DC homeostasis with increased signaling, leading to downmodulation of IL-12 synthesis and worsened disease outcome after infection with Leishmania major. Thus, the complex regulation of various members of the IL-1 cytokine family mediated through effects on both DCs and T cells critically contributes to disease outcome against this important human pathogen."xsd:string |
| http://purl.uniprot.org/citations/21525884 | http://purl.org/dc/terms/identifier | "doi:10.1038/jid.2011.99"xsd:string |
| http://purl.uniprot.org/citations/21525884 | http://purl.uniprot.org/core/author | "Iwakura Y."xsd:string |
| http://purl.uniprot.org/citations/21525884 | http://purl.uniprot.org/core/author | "Udey M.C."xsd:string |
| http://purl.uniprot.org/citations/21525884 | http://purl.uniprot.org/core/author | "von Stebut E."xsd:string |
| http://purl.uniprot.org/citations/21525884 | http://purl.uniprot.org/core/author | "Kostka S.L."xsd:string |
| http://purl.uniprot.org/citations/21525884 | http://purl.uniprot.org/core/author | "Dinges S."xsd:string |
| http://purl.uniprot.org/citations/21525884 | http://purl.uniprot.org/core/author | "Kautz-Neu K."xsd:string |
| http://purl.uniprot.org/citations/21525884 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21525884 | http://purl.uniprot.org/core/name | "J Invest Dermatol"xsd:string |
| http://purl.uniprot.org/citations/21525884 | http://purl.uniprot.org/core/pages | "1650-1659"xsd:string |
| http://purl.uniprot.org/citations/21525884 | http://purl.uniprot.org/core/title | "A role for leukocyte-derived IL-1RA in DC homeostasis revealed by increased susceptibility of IL-1RA-deficient mice to cutaneous leishmaniasis."xsd:string |
| http://purl.uniprot.org/citations/21525884 | http://purl.uniprot.org/core/volume | "131"xsd:string |
| http://purl.uniprot.org/citations/21525884 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21525884 |
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| http://purl.uniprot.org/uniprot/#_Q32MH0-mappedCitation-21525884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21525884 |
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| http://purl.uniprot.org/uniprot/#_Q542C7-mappedCitation-21525884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21525884 |
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| http://purl.uniprot.org/uniprot/#_Q8C833-mappedCitation-21525884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21525884 |