| http://purl.uniprot.org/citations/21527636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21527636 | http://www.w3.org/2000/01/rdf-schema#comment | "In adult rat brains, brain-derived neurotrophic factor (BDNF) rhythmically oscillates according to the light-dark cycle and exhibits unique functions in particular brain regions. However, little is known of this subject in juvenile rats. Here, we examined diurnal variation in BDNF and neurotrophin-3 (NT-3) levels in 14-day-old rats. BDNF levels were high in the dark phase and low in the light phase in a majority of brain regions. In contrast, NT-3 levels demonstrated an inverse phase relationship that was limited to the cerebral neocortex, including the visual cortex, and was most prominent on postnatal day 14. An 8-h phase advance of the light-dark cycle and sleep deprivation induced an increase in BDNF levels and a decrease in NT-3 levels in the neocortex, and the former treatment reduced synaptophysin expression and the numbers of synaptophysin-positive presynaptic terminals in cortical layer IV and caused abnormal BDNF and NT-3 rhythms 1 week after treatment. A similar reduction of synaptophysin expression was observed in the cortices of Bdnf gene-deficient mice and Ca(2+)-dependent activator protein for secretion 2 gene-deficient mice with abnormal free-running rhythm and autistic-like phenotypes. In the latter mice, no diurnal variation in BDNF levels was observed. These results indicate that regular rhythms of BDNF and NT-3 are essential for correct cortical network formation in juvenile rodents."xsd:string |
| http://purl.uniprot.org/citations/21527636 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.195859"xsd:string |
| http://purl.uniprot.org/citations/21527636 | http://purl.uniprot.org/core/author | "Hata Y."xsd:string |
| http://purl.uniprot.org/citations/21527636 | http://purl.uniprot.org/core/author | "Miyazaki N."xsd:string |
| http://purl.uniprot.org/citations/21527636 | http://purl.uniprot.org/core/author | "Matsuda M."xsd:string |
| http://purl.uniprot.org/citations/21527636 | http://purl.uniprot.org/core/author | "Nagata K."xsd:string |
| http://purl.uniprot.org/citations/21527636 | http://purl.uniprot.org/core/author | "Furuichi T."xsd:string |
| http://purl.uniprot.org/citations/21527636 | http://purl.uniprot.org/core/author | "Furuya A."xsd:string |
| http://purl.uniprot.org/citations/21527636 | http://purl.uniprot.org/core/author | "Sudo K."xsd:string |
| http://purl.uniprot.org/citations/21527636 | http://purl.uniprot.org/core/author | "Nakagawa C."xsd:string |
| http://purl.uniprot.org/citations/21527636 | http://purl.uniprot.org/core/author | "Katoh-Semba R."xsd:string |
| http://purl.uniprot.org/citations/21527636 | http://purl.uniprot.org/core/author | "Sadakata T."xsd:string |
| http://purl.uniprot.org/citations/21527636 | http://purl.uniprot.org/core/author | "Hamatake M."xsd:string |
| http://purl.uniprot.org/citations/21527636 | http://purl.uniprot.org/core/author | "Ichisaka S."xsd:string |
| http://purl.uniprot.org/citations/21527636 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21527636 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/21527636 | http://purl.uniprot.org/core/pages | "21478-21487"xsd:string |
| http://purl.uniprot.org/citations/21527636 | http://purl.uniprot.org/core/title | "Phase advance of the light-dark cycle perturbs diurnal rhythms of brain-derived neurotrophic factor and neurotrophin-3 protein levels, which reduces synaptophysin-positive presynaptic terminals in the cortex of juvenile rats."xsd:string |
| http://purl.uniprot.org/citations/21527636 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/21527636 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21527636 |
| http://purl.uniprot.org/citations/21527636 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21527636 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K624-mappedCitation-21527636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21527636 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JVQ7-mappedCitation-21527636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21527636 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JXV7-mappedCitation-21527636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21527636 |