| http://purl.uniprot.org/citations/21529712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21529712 | http://www.w3.org/2000/01/rdf-schema#comment | "Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather than regulatory capacity in mRNA translation. Here we identify mutations of the Ribosomal Protein L38 (Rpl38) gene in mice exhibiting surprising tissue-specific patterning defects, including pronounced homeotic transformations of the axial skeleton. In Rpl38 mutant embryos, global protein synthesis is unchanged; however the translation of a select subset of Homeobox mRNAs is perturbed. Our data reveal that RPL38 facilitates 80S complex formation on these mRNAs as a regulatory component of the ribosome to confer transcript-specific translational control. We further show that Rpl38 expression is markedly enriched in regions of the embryo where loss-of-function phenotypes occur. Unexpectedly, a ribosomal protein (RP) expression screen reveals dynamic regulation of individual RPs within the vertebrate embryo. Collectively, these findings suggest that RP activity may be highly regulated to impart a new layer of specificity in the control of gene expression and mammalian development."xsd:string |
| http://purl.uniprot.org/citations/21529712 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2011.03.028"xsd:string |
| http://purl.uniprot.org/citations/21529712 | http://purl.uniprot.org/core/author | "Shimizu K."xsd:string |
| http://purl.uniprot.org/citations/21529712 | http://purl.uniprot.org/core/author | "Ishijima J."xsd:string |
| http://purl.uniprot.org/citations/21529712 | http://purl.uniprot.org/core/author | "Shiroishi T."xsd:string |
| http://purl.uniprot.org/citations/21529712 | http://purl.uniprot.org/core/author | "Barna M."xsd:string |
| http://purl.uniprot.org/citations/21529712 | http://purl.uniprot.org/core/author | "Stumpf C.R."xsd:string |
| http://purl.uniprot.org/citations/21529712 | http://purl.uniprot.org/core/author | "Hsieh A.C."xsd:string |
| http://purl.uniprot.org/citations/21529712 | http://purl.uniprot.org/core/author | "Pusic A."xsd:string |
| http://purl.uniprot.org/citations/21529712 | http://purl.uniprot.org/core/author | "Kondrashov N."xsd:string |
| http://purl.uniprot.org/citations/21529712 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21529712 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/21529712 | http://purl.uniprot.org/core/pages | "383-397"xsd:string |
| http://purl.uniprot.org/citations/21529712 | http://purl.uniprot.org/core/title | "Ribosome-mediated specificity in Hox mRNA translation and vertebrate tissue patterning."xsd:string |
| http://purl.uniprot.org/citations/21529712 | http://purl.uniprot.org/core/volume | "145"xsd:string |
| http://purl.uniprot.org/citations/21529712 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21529712 |
| http://purl.uniprot.org/citations/21529712 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21529712 |
| http://purl.uniprot.org/uniprot/Q9JJI8#attribution-6182317DF47331EA08A3C104136F0DFE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21529712 |
| http://purl.uniprot.org/uniprot/Q9JJI8#attribution-97506115A6DC0C9541297A2C246347FF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21529712 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVW4-mappedCitation-21529712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21529712 |
| http://purl.uniprot.org/uniprot/#_A0A087WQK0-mappedCitation-21529712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21529712 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YX26-mappedCitation-21529712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21529712 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXL3-mappedCitation-21529712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21529712 |
| http://purl.uniprot.org/uniprot/#_D3Z7I1-mappedCitation-21529712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21529712 |