| http://purl.uniprot.org/citations/21529718 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21529718 | http://www.w3.org/2000/01/rdf-schema#comment | "High-content screening for gene profiling has generally been limited to single cells. Here, we explore an alternative approach-profiling gene function by analyzing effects of gene knockdowns on the architecture of a complex tissue in a multicellular organism. We profile 554 essential C. elegans genes by imaging gonad architecture and scoring 94 phenotypic features. To generate a reference for evaluating methods for network construction, genes were manually partitioned into 102 phenotypic classes, predicting functions for uncharacterized genes across diverse cellular processes. Using this classification as a benchmark, we developed a robust computational method for constructing gene networks from high-content profiles based on a network context-dependent measure that ranks the significance of links between genes. Our analysis reveals that multi-parametric profiling in a complex tissue yields functional maps with a resolution similar to genetic interaction-based profiling in unicellular eukaryotes-pinpointing subunits of macromolecular complexes and components functioning in common cellular processes."xsd:string |
| http://purl.uniprot.org/citations/21529718 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2011.03.037"xsd:string |
| http://purl.uniprot.org/citations/21529718 | http://purl.uniprot.org/core/author | "Desai A."xsd:string |
| http://purl.uniprot.org/citations/21529718 | http://purl.uniprot.org/core/author | "Hyman A.A."xsd:string |
| http://purl.uniprot.org/citations/21529718 | http://purl.uniprot.org/core/author | "Oegema K."xsd:string |
| http://purl.uniprot.org/citations/21529718 | http://purl.uniprot.org/core/author | "Niessen S."xsd:string |
| http://purl.uniprot.org/citations/21529718 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/21529718 | http://purl.uniprot.org/core/author | "Schedl T."xsd:string |
| http://purl.uniprot.org/citations/21529718 | http://purl.uniprot.org/core/author | "Starr D.A."xsd:string |
| http://purl.uniprot.org/citations/21529718 | http://purl.uniprot.org/core/author | "Audhya A."xsd:string |
| http://purl.uniprot.org/citations/21529718 | http://purl.uniprot.org/core/author | "Schloissnig S."xsd:string |
| http://purl.uniprot.org/citations/21529718 | http://purl.uniprot.org/core/author | "Piano F."xsd:string |
| http://purl.uniprot.org/citations/21529718 | http://purl.uniprot.org/core/author | "Green R.A."xsd:string |
| http://purl.uniprot.org/citations/21529718 | http://purl.uniprot.org/core/author | "Fridolfsson H.N."xsd:string |
| http://purl.uniprot.org/citations/21529718 | http://purl.uniprot.org/core/author | "Gunsalus K.C."xsd:string |
| http://purl.uniprot.org/citations/21529718 | http://purl.uniprot.org/core/author | "Schulman M."xsd:string |
| http://purl.uniprot.org/citations/21529718 | http://purl.uniprot.org/core/author | "Arur S."xsd:string |
| http://purl.uniprot.org/citations/21529718 | http://purl.uniprot.org/core/author | "Mayers J.R."xsd:string |
| http://purl.uniprot.org/citations/21529718 | http://purl.uniprot.org/core/author | "Kao H.L."xsd:string |
| http://purl.uniprot.org/citations/21529718 | http://purl.uniprot.org/core/author | "Laband K."xsd:string |
| http://purl.uniprot.org/citations/21529718 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21529718 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/21529718 | http://purl.uniprot.org/core/pages | "470-482"xsd:string |
| http://purl.uniprot.org/citations/21529718 | http://purl.uniprot.org/core/title | "A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue."xsd:string |