| http://purl.uniprot.org/citations/21535077 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21535077 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of this study was to investigate association of human leucocyte antigens (HLA)-DRB1 and DQB1 polymorphisms with hepatitis C virus (HCV) infection and with the occurrence of severe liver fibrosis/cirrhosis in chronically infected patients. Ninety-nine white patients, from southeast Brazil, with confirmed HCV chronic infection were included in the study. Severe fibrosis/cirrhosis (METAVIR scores F3-F4) was present in 49 patients. HLA-DRB1 specificities and DRB1*11 and DQB1* alleles were determined by PCR-SSP, and their frequencies were compared between patients and a control group of 103 healthy white Brazilian individuals. The results confirmed previous reports of the association of DRB1*11 and DQB1*03 with protection from chronic HCV infection, but did not confirm their association with protection from severe fibrosis/cirrhosis. Furthermore, the results suggested that the polymorphic sites on HLA molecules responsible for protection from chronic HCV infection are encoded not only by the DRB1*1101 and DQB1*0301, as suggested in the literature, but also by other DRB1*11 and DQB1*03 alleles. Thus, we hypothesized that the common polymorphic residues shared by different DRB1*11 and/or DQB1*03 alleles might be responsible for selection of viral epitopes for presentation to CD4(+) T cells, leading to an efficient immune response against the virus."xsd:string |
| http://purl.uniprot.org/citations/21535077 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-3083.2011.02568.x"xsd:string |
| http://purl.uniprot.org/citations/21535077 | http://purl.uniprot.org/core/author | "Teixeira R."xsd:string |
| http://purl.uniprot.org/citations/21535077 | http://purl.uniprot.org/core/author | "Gerbase-DeLima M."xsd:string |
| http://purl.uniprot.org/citations/21535077 | http://purl.uniprot.org/core/author | "Rampim G.F."xsd:string |
| http://purl.uniprot.org/citations/21535077 | http://purl.uniprot.org/core/author | "Martins-Filho O.A."xsd:string |
| http://purl.uniprot.org/citations/21535077 | http://purl.uniprot.org/core/author | "Campos E.F."xsd:string |
| http://purl.uniprot.org/citations/21535077 | http://purl.uniprot.org/core/author | "Cangussu L.O.F."xsd:string |
| http://purl.uniprot.org/citations/21535077 | http://purl.uniprot.org/core/author | "Mingoti S.A."xsd:string |
| http://purl.uniprot.org/citations/21535077 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21535077 | http://purl.uniprot.org/core/name | "Scand J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21535077 | http://purl.uniprot.org/core/pages | "282-287"xsd:string |
| http://purl.uniprot.org/citations/21535077 | http://purl.uniprot.org/core/title | "HLA class II alleles and chronic hepatitis C virus infection."xsd:string |
| http://purl.uniprot.org/citations/21535077 | http://purl.uniprot.org/core/volume | "74"xsd:string |
| http://purl.uniprot.org/citations/21535077 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21535077 |
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