| http://purl.uniprot.org/citations/21536799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21536799 | http://www.w3.org/2000/01/rdf-schema#comment | "The immunopathogenesis of Chlamydia trachomatis-induced oviduct pathological sequelae is not well understood. Mice genetically deficient in perforin (perforin(-/-) mice) or tumor necrosis factor alpha (TNF-α) production (TNF-α(-/-) mice) displayed comparable vaginal chlamydial clearance rates but significantly reduced oviduct pathology (hydrosalpinx) compared to that of wild-type mice. Since both perforin and TNF-α are effector mechanisms of CD8(+) T cells, we evaluated the role of CD8(+) T cells during genital Chlamydia muridarum infection and oviduct sequelae. Following vaginal chlamydial challenge, (i) mice deficient in TAP I (and therefore the major histocompatibility complex [MHC] I pathway and CD8(+) T cells), (ii) wild-type mice depleted of CD8(+) T cells, and (iii) mice genetically deficient in CD8 (CD8(-/-) mice) all displayed similar levels of vaginal chlamydial clearance but significantly reduced hydrosalpinx, compared to those of wild-type C57BL/6 mice, suggesting a role for CD8(+) T cells in chlamydial pathogenesis. Repletion of CD8(-/-) mice with wild-type or perforin(-/-), but not TNF-α(-/-), CD8(+) T cells at the time of challenge restored hydrosalpinx to levels observed in wild-type C57BL/6 mice, suggesting that TNF-α production from CD8(+) T cells is important for pathogenesis. Additionally, repletion of TNF-α(-/-) mice with TNF-α(+/+) CD8(+) T cells significantly enhanced the incidence of hydrosalpinx and oviduct dilatation compared to those of TNF-α(-/-) mice but not to the levels found in wild-type mice, suggesting that TNF-α production from CD8(+) T cells and non-CD8(+) cells cooperates to induce optimal oviduct pathology following genital chlamydial infection. These results provide compelling new evidence supporting the contribution of CD8(+) T cells and TNF-α production to Chlamydia-induced reproductive tract sequelae."xsd:string |
| http://purl.uniprot.org/citations/21536799 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.05022-11"xsd:string |
| http://purl.uniprot.org/citations/21536799 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/21536799 | http://purl.uniprot.org/core/author | "Zhong G."xsd:string |
| http://purl.uniprot.org/citations/21536799 | http://purl.uniprot.org/core/author | "Seshu J."xsd:string |
| http://purl.uniprot.org/citations/21536799 | http://purl.uniprot.org/core/author | "Kamalakaran S."xsd:string |
| http://purl.uniprot.org/citations/21536799 | http://purl.uniprot.org/core/author | "Arulanandam B.P."xsd:string |
| http://purl.uniprot.org/citations/21536799 | http://purl.uniprot.org/core/author | "Murthy A.K."xsd:string |
| http://purl.uniprot.org/citations/21536799 | http://purl.uniprot.org/core/author | "Guentzel M.N."xsd:string |
| http://purl.uniprot.org/citations/21536799 | http://purl.uniprot.org/core/author | "Forsthuber T.G."xsd:string |
| http://purl.uniprot.org/citations/21536799 | http://purl.uniprot.org/core/author | "Chaganty B.K."xsd:string |
| http://purl.uniprot.org/citations/21536799 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21536799 | http://purl.uniprot.org/core/name | "Infect Immun"xsd:string |
| http://purl.uniprot.org/citations/21536799 | http://purl.uniprot.org/core/pages | "2928-2935"xsd:string |
| http://purl.uniprot.org/citations/21536799 | http://purl.uniprot.org/core/title | "Tumor necrosis factor alpha production from CD8+ T cells mediates oviduct pathological sequelae following primary genital Chlamydia muridarum infection."xsd:string |
| http://purl.uniprot.org/citations/21536799 | http://purl.uniprot.org/core/volume | "79"xsd:string |
| http://purl.uniprot.org/citations/21536799 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21536799 |
| http://purl.uniprot.org/citations/21536799 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21536799 |
| http://purl.uniprot.org/uniprot/#_A0A068BER1-mappedCitation-21536799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21536799 |
| http://purl.uniprot.org/uniprot/#_Q0X0E6-mappedCitation-21536799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21536799 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J210-mappedCitation-21536799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21536799 |
| http://purl.uniprot.org/uniprot/#_A0A0U5J4W4-mappedCitation-21536799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21536799 |
| http://purl.uniprot.org/uniprot/#_A2RSY7-mappedCitation-21536799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21536799 |
| http://purl.uniprot.org/uniprot/#_F6QHF1-mappedCitation-21536799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21536799 |