| http://purl.uniprot.org/citations/21536891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21536891 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs (miRNAs) modulate complex physiological and pathological processes by repressing expression of multiple components of cellular regulatory networks. Here we demonstrate that miRNAs encoded by the miR-23∼27∼24 gene clusters are enriched in endothelial cells and highly vascularized tissues. Inhibition of miR-23 and miR-27 function by locked nucleic acid-modified anti-miRNAs represses angiogenesis in vitro and postnatal retinal vascular development in vivo. Moreover, miR-23 and miR-27 are required for pathological angiogenesis in a laser-induced choroidal neovascularization mouse model. MiR-23 and miR-27 enhance angiogenesis by promoting angiogenic signaling through targeting Sprouty2 and Sema6A proteins, which exert antiangiogenic activity. Manipulating miR-23/27 levels may have important therapeutic implications in neovascular age-related macular degeneration and other vascular disorders."xsd:string |
| http://purl.uniprot.org/citations/21536891 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1105254108"xsd:string |
| http://purl.uniprot.org/citations/21536891 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/21536891 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/21536891 | http://purl.uniprot.org/core/author | "Zhou Q."xsd:string |
| http://purl.uniprot.org/citations/21536891 | http://purl.uniprot.org/core/author | "Olson E.N."xsd:string |
| http://purl.uniprot.org/citations/21536891 | http://purl.uniprot.org/core/author | "Ufret-Vincenty R."xsd:string |
| http://purl.uniprot.org/citations/21536891 | http://purl.uniprot.org/core/author | "Gallagher R."xsd:string |
| http://purl.uniprot.org/citations/21536891 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21536891 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/21536891 | http://purl.uniprot.org/core/pages | "8287-8292"xsd:string |
| http://purl.uniprot.org/citations/21536891 | http://purl.uniprot.org/core/title | "Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters."xsd:string |
| http://purl.uniprot.org/citations/21536891 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/21536891 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21536891 |
| http://purl.uniprot.org/citations/21536891 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21536891 |
| http://purl.uniprot.org/uniprot/Q9H2E6#attribution-13E6800DD05681B4C541A0DC7693B8F9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21536891 |
| http://purl.uniprot.org/uniprot/O43597#attribution-13E6800DD05681B4C541A0DC7693B8F9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21536891 |