| http://purl.uniprot.org/citations/21538979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21538979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21538979 | http://www.w3.org/2000/01/rdf-schema#comment | "Binding of specific antigenic peptides with human leukocyte antigen (HLA) molecules is a prerequisite for the initiation of T-cell responses and structural information about the peptide-HLA complex is essential for the detailed understanding of such interactions. HLA-A2 is the most prevalent HLA allele globally but aside from A*02:01 there is a significant lack of crystal structures, particularly for alleles that occur in high frequencies among Asian populations. Here, we report three HLA-A2 structures with the immunodominant hepatitis B core antigen 18-27 (HBcAg18-27) epitope, namely A*02:03, A*02:06, and A*02:07 at resolutions of 2.16, 1.70, and 1.75 Å respectively. This comparative analysis reveals that minor polymorphic residue changes between different HLA alleles can induce significant alterations in the major histocompatibility complex-peptide interface, and introduce conformational changes in the p3-p8 peptide region. Circular dichroism analysis demonstrated the HLA-A2-peptide complexes to have a hierarchy of thermostability and binding affinity in the order of A*02:06>A*02:07>A*02:01>A*02:03. Our findings provide structural insights into the varied HLA-A2 allele binding of the hepatitis B core antigen 18-27 epitope and the data suggest that chemical modifications of the peptide side chains could be a promising strategy to modulate and improve HLA-A2-peptide binding affinity for vaccine design."xsd:string |
| http://purl.uniprot.org/citations/21538979 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201041370"xsd:string |
| http://purl.uniprot.org/citations/21538979 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201041370"xsd:string |
| http://purl.uniprot.org/citations/21538979 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/21538979 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/21538979 | http://purl.uniprot.org/core/author | "Ren E.C."xsd:string |
| http://purl.uniprot.org/citations/21538979 | http://purl.uniprot.org/core/author | "Ren E.C."xsd:string |
| http://purl.uniprot.org/citations/21538979 | http://purl.uniprot.org/core/author | "Chen K.Y."xsd:string |
| http://purl.uniprot.org/citations/21538979 | http://purl.uniprot.org/core/author | "Chen K.Y."xsd:string |
| http://purl.uniprot.org/citations/21538979 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21538979 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21538979 | http://purl.uniprot.org/core/name | "Eur. J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/21538979 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21538979 | http://purl.uniprot.org/core/pages | "2097-2106"xsd:string |
| http://purl.uniprot.org/citations/21538979 | http://purl.uniprot.org/core/pages | "2097-2106"xsd:string |
| http://purl.uniprot.org/citations/21538979 | http://purl.uniprot.org/core/title | "Structural insights into the binding of hepatitis B virus core peptide to HLA-A2 alleles: towards designing better vaccines."xsd:string |
| http://purl.uniprot.org/citations/21538979 | http://purl.uniprot.org/core/title | "Structural insights into the binding of hepatitis B virus core peptide to HLA-A2 alleles: towards designing better vaccines."xsd:string |
| http://purl.uniprot.org/citations/21538979 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/21538979 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/21538979 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21538979 |
| http://purl.uniprot.org/citations/21538979 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21538979 |
| http://purl.uniprot.org/citations/21538979 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21538979 |
| http://purl.uniprot.org/citations/21538979 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21538979 |