| http://purl.uniprot.org/citations/21539827 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21539827 | http://www.w3.org/2000/01/rdf-schema#comment | "We report that the disruption of bidirectional signaling between ephrin-B2 and EphB receptors impairs morphogenetic cell-cell septation and closure events during development of the embryonic midline. A novel role for reverse signaling is identified in tracheoesophageal foregut septation, as animals lacking the cytoplasmic domain of ephrin-B2 present with laryngotracheoesophageal cleft (LTEC), while both EphB2/EphB3 forward signaling and ephrin-B2 reverse signaling are shown to be required for midline fusion of the palate. In a third midline event, EphB2/EphB3 are shown to mediate ventral abdominal wall closure by acting principally as ligands to stimulate ephrin-B reverse signaling. Analysis of new ephrin-B2(6YFΔV) and ephrin-B2(ΔV) mutants that specifically ablate ephrin-B2 tyrosine phosphorylation-and/or PDZ domain-mediated signaling indicates there are at least two distinct phosphorylation-independent components of reverse signaling. These involve both PDZ domain interactions and a non-canonical SH2/PDZ-independent form of reverse signaling that may utilize associations with claudin family tetraspan molecules, as EphB2 and activated ephrin-B2 molecules are specifically co-localized with claudins in epithelia at the point of septation. Finally, the developmental phenotypes described here mirror common human midline birth defects found with the VACTERL association, suggesting a molecular link to bidirectional signaling through B-subclass Ephs and ephrins."xsd:string |
| http://purl.uniprot.org/citations/21539827 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2011.04.020"xsd:string |
| http://purl.uniprot.org/citations/21539827 | http://purl.uniprot.org/core/author | "Henkemeyer M."xsd:string |
| http://purl.uniprot.org/citations/21539827 | http://purl.uniprot.org/core/author | "Dravis C."xsd:string |
| http://purl.uniprot.org/citations/21539827 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21539827 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/21539827 | http://purl.uniprot.org/core/pages | "138-151"xsd:string |
| http://purl.uniprot.org/citations/21539827 | http://purl.uniprot.org/core/title | "Ephrin-B reverse signaling controls septation events at the embryonic midline through separate tyrosine phosphorylation-independent signaling avenues."xsd:string |
| http://purl.uniprot.org/citations/21539827 | http://purl.uniprot.org/core/volume | "355"xsd:string |
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