| http://purl.uniprot.org/citations/21543745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21543745 | http://www.w3.org/2000/01/rdf-schema#comment | "Fibroblast growth factor 2 (FGF-2) and its main receptor FGFR1 have been shown to promote hepatic stellate cell (HSC) activation and proliferation. However, scant information is available on the anti-fibrogenic activity of FGFR1 inhibitors. The aim of this study was to assess the impact of a selective FGFR1 tyrosine kinase inhibitor NP603 on HSC proliferation and hepatic fibrosis. We demonstrated that rat primary HSCs secreted significant amounts of FGF-2, and its tyrosine phosphorylation of FGFR1 was attenuated by NP603. NP603 inhibited HSC activaton by measuring the expression of α-smooth muscle actin (α-SMA) and the production of type I collagen using ELISA. Furthermore, NP603 (25 μM) in vitro strongly suppressed HSC growth induced by FGF-2 (10 ng/ml) and FCS. This effect correlated with the suppression of extracellular-regulated kinase (ERK) activity and its downstream targets cyclin D1 and p21. In addition, PO NP603 (20 mg·kg(-1)·day(-1)) administration significantly decreased hepatic collagen deposition and α-SMA expression in CCl(4)-treated rats. Collectively, these studies suggest that selective blocking of the FGFR1-mediated pathway could be a promising therapeutic approach for the treatment of hepatic fibrosis."xsd:string |
| http://purl.uniprot.org/citations/21543745 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpcell.00452.2010"xsd:string |
| http://purl.uniprot.org/citations/21543745 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/21543745 | http://purl.uniprot.org/core/author | "Hu K."xsd:string |
| http://purl.uniprot.org/citations/21543745 | http://purl.uniprot.org/core/author | "Pan W."xsd:string |
| http://purl.uniprot.org/citations/21543745 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/21543745 | http://purl.uniprot.org/core/author | "Xu R."xsd:string |
| http://purl.uniprot.org/citations/21543745 | http://purl.uniprot.org/core/author | "Lin N."xsd:string |
| http://purl.uniprot.org/citations/21543745 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21543745 | http://purl.uniprot.org/core/name | "Am J Physiol Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/21543745 | http://purl.uniprot.org/core/pages | "C469-77"xsd:string |
| http://purl.uniprot.org/citations/21543745 | http://purl.uniprot.org/core/title | "NP603, a novel and potent inhibitor of FGFR1 tyrosine kinase, inhibits hepatic stellate cell proliferation and ameliorates hepatic fibrosis in rats."xsd:string |
| http://purl.uniprot.org/citations/21543745 | http://purl.uniprot.org/core/volume | "301"xsd:string |
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