| http://purl.uniprot.org/citations/21543847 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21543847 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21543847 | http://www.w3.org/2000/01/rdf-schema#comment | "The structure of the human major histocompatability (MHC) class I molecule HLA-A*0301 (HLA-A3) in complex with a nonameric peptide (KLIETYFSK) has been determined by X-ray crystallography to 2.7 Å resolution. HLA-A3 is a predisposing allele for multiple sclerosis (MS), an autoimmune disease of the central nervous system. The KLIETYFSK peptide is a naturally processed epitope of proteolipid protein, a myelin protein and candidate target for immune-mediated myelin destruction in MS. Comparison of the structure of HLA-A3 with that of HLA-A2, an MHC class I molecule which is protective against MS, indicates that both MHC class I molecules present very similar faces for T-cell receptor recognition whilst differing in the specificity of their peptide-binding grooves. These characteristics may underlie the opposing (predisposing versus protective) associations that they exhibit both in humans and in mouse models of MS-like disease. Furthermore, subtle alterations within the peptide-binding groove of HLA-A3 and other A3-like MHC class I molecules, members of the so-called A3 superfamily, may be sufficient to alter their presentation of autoantigen peptides such as KLIETYFSK. This in turn may modulate their contribution to the associated risk of autoimmune disease."xsd:string |
| http://purl.uniprot.org/citations/21543847 | http://purl.org/dc/terms/identifier | "doi:10.1107/s0907444911007888"xsd:string |
| http://purl.uniprot.org/citations/21543847 | http://purl.org/dc/terms/identifier | "doi:10.1107/s0907444911007888"xsd:string |
| http://purl.uniprot.org/citations/21543847 | http://purl.uniprot.org/core/author | "Fugger L."xsd:string |
| http://purl.uniprot.org/citations/21543847 | http://purl.uniprot.org/core/author | "Fugger L."xsd:string |
| http://purl.uniprot.org/citations/21543847 | http://purl.uniprot.org/core/author | "Jones E.Y."xsd:string |
| http://purl.uniprot.org/citations/21543847 | http://purl.uniprot.org/core/author | "Jones E.Y."xsd:string |
| http://purl.uniprot.org/citations/21543847 | http://purl.uniprot.org/core/author | "Friese M.A."xsd:string |
| http://purl.uniprot.org/citations/21543847 | http://purl.uniprot.org/core/author | "Friese M.A."xsd:string |
| http://purl.uniprot.org/citations/21543847 | http://purl.uniprot.org/core/author | "Siebold C."xsd:string |
| http://purl.uniprot.org/citations/21543847 | http://purl.uniprot.org/core/author | "Siebold C."xsd:string |
| http://purl.uniprot.org/citations/21543847 | http://purl.uniprot.org/core/author | "Friis L."xsd:string |
| http://purl.uniprot.org/citations/21543847 | http://purl.uniprot.org/core/author | "Friis L."xsd:string |
| http://purl.uniprot.org/citations/21543847 | http://purl.uniprot.org/core/author | "McMahon R.M."xsd:string |
| http://purl.uniprot.org/citations/21543847 | http://purl.uniprot.org/core/author | "McMahon R.M."xsd:string |
| http://purl.uniprot.org/citations/21543847 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21543847 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21543847 | http://purl.uniprot.org/core/name | "Acta Crystallogr. D"xsd:string |
| http://purl.uniprot.org/citations/21543847 | http://purl.uniprot.org/core/name | "Acta Crystallogr. D"xsd:string |
| http://purl.uniprot.org/citations/21543847 | http://purl.uniprot.org/core/pages | "447-454"xsd:string |
| http://purl.uniprot.org/citations/21543847 | http://purl.uniprot.org/core/pages | "447-454"xsd:string |
| http://purl.uniprot.org/citations/21543847 | http://purl.uniprot.org/core/title | "Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis."xsd:string |
| http://purl.uniprot.org/citations/21543847 | http://purl.uniprot.org/core/title | "Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis."xsd:string |