| http://purl.uniprot.org/citations/21558367 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21558367 | http://www.w3.org/2000/01/rdf-schema#comment | "Dopaminergic neurons play important behavioral roles in locomotion, reward and aggression. The Drosophila H-cell is a dopaminergic neuron that resides at the midline of the ventral nerve cord. Both the H-cell and the glutamatergic H-cell sib are the asymmetric progeny of the MP3 midline precursor cell. H-cell sib cell fate is dependent on Notch signaling, whereas H-cell fate is Notch independent. Genetic analysis of genes that could potentially regulate H-cell fate revealed that the lethal of scute [l(1)sc], tailup and SoxNeuro transcription factor genes act together to control H-cell gene expression. The l(1)sc bHLH gene is required for all H-cell-specific gene transcription, whereas tailup acts in parallel to l(1)sc and controls genes involved in dopamine metabolism. SoxNeuro functions downstream of l(1)sc and controls expression of a peptide neurotransmitter receptor gene. The role of l(1)sc may be more widespread, as a l(1)sc mutant shows reductions in gene expression in non-midline dopaminergic neurons. In addition, l(1)sc mutant embryos possess defects in the formation of MP4-6 midline precursor and the median neuroblast stem cell, revealing a proneural role for l(1)sc in midline cells. The Notch-dependent progeny of MP4-6 are the mVUM motoneurons, and these cells also require l(1)sc for mVUM-specific gene expression. Thus, l(1)sc plays an important regulatory role in both neurogenesis and specifying dopaminergic neuron and motoneuron identities."xsd:string |
| http://purl.uniprot.org/citations/21558367 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.056507"xsd:string |
| http://purl.uniprot.org/citations/21558367 | http://purl.uniprot.org/core/author | "Crews S.T."xsd:string |
| http://purl.uniprot.org/citations/21558367 | http://purl.uniprot.org/core/author | "Guardiola A.R."xsd:string |
| http://purl.uniprot.org/citations/21558367 | http://purl.uniprot.org/core/author | "Stagg S.B."xsd:string |
| http://purl.uniprot.org/citations/21558367 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21558367 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/21558367 | http://purl.uniprot.org/core/pages | "2171-2183"xsd:string |
| http://purl.uniprot.org/citations/21558367 | http://purl.uniprot.org/core/title | "Dual role for Drosophila lethal of scute in CNS midline precursor formation and dopaminergic neuron and motoneuron cell fate."xsd:string |
| http://purl.uniprot.org/citations/21558367 | http://purl.uniprot.org/core/volume | "138"xsd:string |
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