| http://purl.uniprot.org/citations/21559432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21559432 | http://www.w3.org/2000/01/rdf-schema#comment | "The chromatin remodelling complex B-WICH, which comprises the William syndrome transcription factor (WSTF), SNF2h, and nuclear myosin 1 (NM1), is involved in regulating rDNA transcription, and SiRNA silencing of WSTF leads to a reduced level of 45S pre-rRNA. The mechanism behind the action of B-WICH is unclear. Here, we show that the B-WICH complex affects the chromatin structure and that silencing of the WSTF protein results in a compaction of the chromatin structure over a 200 basepair region at the rRNA promoter. WSTF knock down does not show an effect on the binding of the rRNA-specific enhancer and chromatin protein UBF, which contributes to the chromatin structure at active genes. Instead, WSTF knock down results in a reduced level of acetylated H3-Ac, in particular H3K9-Ac, at the promoter and along the gene. The association of the histone acetyl-transferases PCAF, p300 and GCN5 with the promoter is reduced in WSTF knock down cells, whereas the association of the histone acetyl-transferase MOF is retained. A low level of H3-Ac was also found in growing cells, but here histone acetyl-transferases were present at the rDNA promoter. We propose that the B-WICH complex remodels the chromatin structure at actively transcribed rRNA genes, and this allows for the association of specific histone acetyl-transferases."xsd:string |
| http://purl.uniprot.org/citations/21559432 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0019184"xsd:string |
| http://purl.uniprot.org/citations/21559432 | http://purl.uniprot.org/core/author | "Bohm S."xsd:string |
| http://purl.uniprot.org/citations/21559432 | http://purl.uniprot.org/core/author | "Percipalle P."xsd:string |
| http://purl.uniprot.org/citations/21559432 | http://purl.uniprot.org/core/author | "Louvet E."xsd:string |
| http://purl.uniprot.org/citations/21559432 | http://purl.uniprot.org/core/author | "Sadeghifar F."xsd:string |
| http://purl.uniprot.org/citations/21559432 | http://purl.uniprot.org/core/author | "Ostlund Farrants A.K."xsd:string |
| http://purl.uniprot.org/citations/21559432 | http://purl.uniprot.org/core/author | "Mansen A."xsd:string |
| http://purl.uniprot.org/citations/21559432 | http://purl.uniprot.org/core/author | "Vintermist A."xsd:string |
| http://purl.uniprot.org/citations/21559432 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21559432 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/21559432 | http://purl.uniprot.org/core/pages | "e19184"xsd:string |
| http://purl.uniprot.org/citations/21559432 | http://purl.uniprot.org/core/title | "The chromatin remodelling complex B-WICH changes the chromatin structure and recruits histone acetyl-transferases to active rRNA genes."xsd:string |
| http://purl.uniprot.org/citations/21559432 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/21559432 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21559432 |
| http://purl.uniprot.org/citations/21559432 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21559432 |
| http://purl.uniprot.org/uniprot/#_Q15572-mappedCitation-21559432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21559432 |
| http://purl.uniprot.org/uniprot/#_Q15573-mappedCitation-21559432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21559432 |
| http://purl.uniprot.org/uniprot/#_O15160-mappedCitation-21559432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21559432 |
| http://purl.uniprot.org/uniprot/#_P35659-mappedCitation-21559432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21559432 |
| http://purl.uniprot.org/uniprot/#_P49841-mappedCitation-21559432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21559432 |
| http://purl.uniprot.org/uniprot/#_P52434-mappedCitation-21559432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21559432 |
| http://purl.uniprot.org/uniprot/#_Q3B726-mappedCitation-21559432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21559432 |
| http://purl.uniprot.org/uniprot/#_O95602-mappedCitation-21559432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21559432 |