| http://purl.uniprot.org/citations/21562564 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21562564 | http://www.w3.org/2000/01/rdf-schema#comment | "Notch signalling is a central regulator of differentiation in a variety of organisms and tissue types. Its activity is controlled by the multi-subunit γ-secretase (γSE) complex. Although Notch signalling can play both oncogenic and tumour-suppressor roles in solid tumours, in the haematopoietic system it is exclusively oncogenic, notably in T-cell acute lymphoblastic leukaemia, a disease characterized by Notch1-activating mutations. Here we identify novel somatic-inactivating Notch pathway mutations in a fraction of patients with chronic myelomonocytic leukaemia (CMML). Inactivation of Notch signalling in mouse haematopoietic stem cells (HSCs) results in an aberrant accumulation of granulocyte/monocyte progenitors (GMPs), extramedullary haematopoieisis and the induction of CMML-like disease. Transcriptome analysis revealed that Notch signalling regulates an extensive myelomonocytic-specific gene signature, through the direct suppression of gene transcription by the Notch target Hes1. Our studies identify a novel role for Notch signalling during early haematopoietic stem cell differentiation and suggest that the Notch pathway can play both tumour-promoting and -suppressive roles within the same tissue."xsd:string |
| http://purl.uniprot.org/citations/21562564 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature09999"xsd:string |
| http://purl.uniprot.org/citations/21562564 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/21562564 | http://purl.uniprot.org/core/author | "Efstratiadis A."xsd:string |
| http://purl.uniprot.org/citations/21562564 | http://purl.uniprot.org/core/author | "Abdel-Wahab O."xsd:string |
| http://purl.uniprot.org/citations/21562564 | http://purl.uniprot.org/core/author | "Levine R.L."xsd:string |
| http://purl.uniprot.org/citations/21562564 | http://purl.uniprot.org/core/author | "Zavadil J."xsd:string |
| http://purl.uniprot.org/citations/21562564 | http://purl.uniprot.org/core/author | "Lobry C."xsd:string |
| http://purl.uniprot.org/citations/21562564 | http://purl.uniprot.org/core/author | "Beran M."xsd:string |
| http://purl.uniprot.org/citations/21562564 | http://purl.uniprot.org/core/author | "Ibrahim S."xsd:string |
| http://purl.uniprot.org/citations/21562564 | http://purl.uniprot.org/core/author | "Aifantis I."xsd:string |
| http://purl.uniprot.org/citations/21562564 | http://purl.uniprot.org/core/author | "Trimarchi T."xsd:string |
| http://purl.uniprot.org/citations/21562564 | http://purl.uniprot.org/core/author | "Oh P."xsd:string |
| http://purl.uniprot.org/citations/21562564 | http://purl.uniprot.org/core/author | "Araldi E."xsd:string |
| http://purl.uniprot.org/citations/21562564 | http://purl.uniprot.org/core/author | "Cathelin S."xsd:string |
| http://purl.uniprot.org/citations/21562564 | http://purl.uniprot.org/core/author | "Buonamici S."xsd:string |
| http://purl.uniprot.org/citations/21562564 | http://purl.uniprot.org/core/author | "Klinakis A."xsd:string |
| http://purl.uniprot.org/citations/21562564 | http://purl.uniprot.org/core/author | "Michor F."xsd:string |
| http://purl.uniprot.org/citations/21562564 | http://purl.uniprot.org/core/author | "Taghon T."xsd:string |
| http://purl.uniprot.org/citations/21562564 | http://purl.uniprot.org/core/author | "Haeno H."xsd:string |
| http://purl.uniprot.org/citations/21562564 | http://purl.uniprot.org/core/author | "van De Walle I."xsd:string |
| http://purl.uniprot.org/citations/21562564 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21562564 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/21562564 | http://purl.uniprot.org/core/pages | "230-233"xsd:string |