| http://purl.uniprot.org/citations/21565331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21565331 | http://www.w3.org/2000/01/rdf-schema#comment | "Recently, BACE1 expression was shown to be regulated by microRNAs, small endogenous RNA molecules that regulate protein expression through sequence-specific interaction with messenger RNA. Here, we showed that microRNA-29c (miR-29c), a miRNA that is enriched in the brain and highly expressed in the APPswe/PSΔE9 mouse lowers BACE1 protein in vitro and in transgenic miR-29c mice. In silico analysis identified two putative target sites in the BACE1 mRNA for the miR-29c family. We chose SH-SY5Y, HEK-293T cell lines and miR-29c transgenic mice for these studies to validate our hypothesis. Significantly, over-expression of miR-29c in SH-SY5Y, HEK-293T cell lines and miR-29c transgenic mice downregulated BACE1 protein levels. Our findings suggest that miR-29c may be an endogenous regulator of BACE1 protein expression."xsd:string |
| http://purl.uniprot.org/citations/21565331 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.brainres.2011.04.035"xsd:string |
| http://purl.uniprot.org/citations/21565331 | http://purl.uniprot.org/core/author | "Dong W."xsd:string |
| http://purl.uniprot.org/citations/21565331 | http://purl.uniprot.org/core/author | "Huang L."xsd:string |
| http://purl.uniprot.org/citations/21565331 | http://purl.uniprot.org/core/author | "Ma C."xsd:string |
| http://purl.uniprot.org/citations/21565331 | http://purl.uniprot.org/core/author | "Qin C."xsd:string |
| http://purl.uniprot.org/citations/21565331 | http://purl.uniprot.org/core/author | "Zhu H."xsd:string |
| http://purl.uniprot.org/citations/21565331 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/21565331 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/21565331 | http://purl.uniprot.org/core/author | "Zong Y."xsd:string |
| http://purl.uniprot.org/citations/21565331 | http://purl.uniprot.org/core/author | "Quan X."xsd:string |
| http://purl.uniprot.org/citations/21565331 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21565331 | http://purl.uniprot.org/core/name | "Brain Res"xsd:string |
| http://purl.uniprot.org/citations/21565331 | http://purl.uniprot.org/core/pages | "108-115"xsd:string |
| http://purl.uniprot.org/citations/21565331 | http://purl.uniprot.org/core/title | "miR-29c regulates BACE1 protein expression."xsd:string |
| http://purl.uniprot.org/citations/21565331 | http://purl.uniprot.org/core/volume | "1395"xsd:string |
| http://purl.uniprot.org/citations/21565331 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21565331 |
| http://purl.uniprot.org/citations/21565331 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21565331 |
| http://purl.uniprot.org/uniprot/#_P56817-mappedCitation-21565331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21565331 |
| http://purl.uniprot.org/uniprot/#_A0A7P0TAB4-mappedCitation-21565331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21565331 |
| http://purl.uniprot.org/uniprot/#_B7Z3K2-mappedCitation-21565331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21565331 |
| http://purl.uniprot.org/uniprot/#_B7Z3Z4-mappedCitation-21565331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21565331 |
| http://purl.uniprot.org/uniprot/#_B3KQJ4-mappedCitation-21565331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21565331 |
| http://purl.uniprot.org/uniprot/#_Q76KP0-mappedCitation-21565331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21565331 |