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http://purl.uniprot.org/citations/21565704http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21565704http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21565704http://www.w3.org/2000/01/rdf-schema#comment"The ZntB Zn(2+) efflux system is important for maintenance of Zn(2+) homeostasis in Enterobacteria. We report crystal structures of ZntB cytoplasmic domains from Salmonella enterica serovar Typhimurium (StZntB) in dimeric and physiologically relevant homopentameric forms at 2.3 Å and 3.1 Å resolutions, respectively. The funnel-like structure is similar to that of the homologous Thermotoga maritima CorA Mg(2+) channel and a Vibrio parahaemolyticus ZntB (VpZntB) soluble domain structure. However, the central α7 helix forming the inner wall of the StZntB funnel is oriented perpendicular to the membrane instead of the marked angle seen in CorA or VpZntB. Consequently, the StZntB funnel pore is cylindrical, not tapered, which may represent an "open" form of the ZntB soluble domain. Our crystal structures and isothermal titration calorimetry data indicate that there are three Zn(2+) binding sites in the full-length ZntB, two of which could be involved in Zn(2+) transport."xsd:string
http://purl.uniprot.org/citations/21565704http://purl.org/dc/terms/identifier"doi:10.1016/j.str.2011.02.011"xsd:string
http://purl.uniprot.org/citations/21565704http://purl.org/dc/terms/identifier"doi:10.1016/j.str.2011.02.011"xsd:string
http://purl.uniprot.org/citations/21565704http://purl.uniprot.org/core/author"Maguire M.E."xsd:string
http://purl.uniprot.org/citations/21565704http://purl.uniprot.org/core/author"Maguire M.E."xsd:string
http://purl.uniprot.org/citations/21565704http://purl.uniprot.org/core/author"Dealwis C."xsd:string
http://purl.uniprot.org/citations/21565704http://purl.uniprot.org/core/author"Dealwis C."xsd:string
http://purl.uniprot.org/citations/21565704http://purl.uniprot.org/core/author"Wan Q."xsd:string
http://purl.uniprot.org/citations/21565704http://purl.uniprot.org/core/author"Wan Q."xsd:string
http://purl.uniprot.org/citations/21565704http://purl.uniprot.org/core/author"Ahmad M.F."xsd:string
http://purl.uniprot.org/citations/21565704http://purl.uniprot.org/core/author"Ahmad M.F."xsd:string
http://purl.uniprot.org/citations/21565704http://purl.uniprot.org/core/author"Fairman J."xsd:string
http://purl.uniprot.org/citations/21565704http://purl.uniprot.org/core/author"Fairman J."xsd:string
http://purl.uniprot.org/citations/21565704http://purl.uniprot.org/core/author"Gorzelle B."xsd:string
http://purl.uniprot.org/citations/21565704http://purl.uniprot.org/core/author"Gorzelle B."xsd:string
http://purl.uniprot.org/citations/21565704http://purl.uniprot.org/core/author"de la Fuente M."xsd:string
http://purl.uniprot.org/citations/21565704http://purl.uniprot.org/core/author"de la Fuente M."xsd:string
http://purl.uniprot.org/citations/21565704http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21565704http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21565704http://purl.uniprot.org/core/name"Structure"xsd:string
http://purl.uniprot.org/citations/21565704http://purl.uniprot.org/core/name"Structure"xsd:string
http://purl.uniprot.org/citations/21565704http://purl.uniprot.org/core/pages"700-710"xsd:string
http://purl.uniprot.org/citations/21565704http://purl.uniprot.org/core/pages"700-710"xsd:string