| http://purl.uniprot.org/citations/21569485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21569485 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundHuman leukocyte antigen (HLA) alleles are associated with many autoimmune diseases, including anti-glomerular basement membrane (GBM) disease. In our previous study, it was demonstrated that HLA-DRB1*1501 was strongly associated with anti-GBM disease in Chinese. However, the association of anti-GBM disease and other HLA class II genes, including HLA-DQB1, -DQA1,-DPB1 alleles, has rarely been investigated in Asian, especially Chinese patients. The present study further analyzed the association between anti-GBM disease and HLA-DQB1, -DQA1, and -DPB1 genes. Apart from this, we tried to locate the potential risk amino acid residues of anti-GBM disease.MethodsThis study included 44 Chinese patients with anti-GBM disease and 200 healthy controls. The clinical and pathological data of the patients were collected and analyzed. Typing of HLA-DQB1, -DQA1 and -DPB1 alleles were performed by bi-directional sequencing of exon 2 using the SeCoreTM Sequencing Kits.ResultsCompared with normal controls, the prevalence of HLA-DPB1*0401 was significantly lower in patients with anti-GBM disease (3/88 vs. 74/400, p = 4.4 × 10-4, pc=0.039). Comparing with normal controls, the combination of presence of DRB1*1501 and absence of DPB1*0401 was significantly prominent among anti-GBM patients (p=2.0 × 10-12, pc=1.7 × 10-10).ConclusionsHLA-DPB1*0401 might be a protective allele to anti-GBM disease in Chinese patients. The combined presence of DRB1*1501 and absence of DPB1*0401 might have an even higher risk to anti-GBM disease than HLA-DRB1*1501 alone."xsd:string |
| http://purl.uniprot.org/citations/21569485 | http://purl.org/dc/terms/identifier | "doi:10.1186/1471-2369-12-21"xsd:string |
| http://purl.uniprot.org/citations/21569485 | http://purl.uniprot.org/core/author | "Chen M."xsd:string |
| http://purl.uniprot.org/citations/21569485 | http://purl.uniprot.org/core/author | "Cui Z."xsd:string |
| http://purl.uniprot.org/citations/21569485 | http://purl.uniprot.org/core/author | "Luo H."xsd:string |
| http://purl.uniprot.org/citations/21569485 | http://purl.uniprot.org/core/author | "Yang R."xsd:string |
| http://purl.uniprot.org/citations/21569485 | http://purl.uniprot.org/core/author | "Zhou X.J."xsd:string |
| http://purl.uniprot.org/citations/21569485 | http://purl.uniprot.org/core/author | "Zhao M.H."xsd:string |
| http://purl.uniprot.org/citations/21569485 | http://purl.uniprot.org/core/author | "Xu P.C."xsd:string |
| http://purl.uniprot.org/citations/21569485 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21569485 | http://purl.uniprot.org/core/name | "BMC Nephrol"xsd:string |
| http://purl.uniprot.org/citations/21569485 | http://purl.uniprot.org/core/pages | "21"xsd:string |
| http://purl.uniprot.org/citations/21569485 | http://purl.uniprot.org/core/title | "The association of HLA-DQB1, -DQA1 and -DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients."xsd:string |
| http://purl.uniprot.org/citations/21569485 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/21569485 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21569485 |
| http://purl.uniprot.org/citations/21569485 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21569485 |
| http://purl.uniprot.org/uniprot/P01911#attribution-76FFCB51A71F23E41EA2B8B130435284 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21569485 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-21569485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21569485 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-21569485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21569485 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-21569485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21569485 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C545-mappedCitation-21569485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21569485 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C550-mappedCitation-21569485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21569485 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C554-mappedCitation-21569485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21569485 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-21569485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21569485 |