| http://purl.uniprot.org/citations/21569759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21569759 | http://www.w3.org/2000/01/rdf-schema#comment | "The cell surface heparan sulfate proteoglycan, syndecan-2, is crucial for the tumorigenic activity of colon cancer cells. However, the role played by the cytoplasmic domain of the protein remains unclear. Using colon cancer cells transfected with various syndecan-2-encoding genes with deletions in the cytoplasmic domain, it was shown that syndecan-2-induced migration activity requires the EFYA sequence of the C-terminal region; deletion of these residues abolished the rise in cell migration seen when the wild-type gene was transfected and syndecan-2 interaction with syntenin-1, suggesting that syntenin-1 functioned as a cytosolic signal effector downstream from syndecan-2. Colon cancer cells transfected with the syntenin-1 gene showed increased migratory activity, whereas migration was decreased in cells in which syntenin-1 was knock-down using small inhibitory RNA. In addition, syntenin-1 expression potentiated colon cancer cell migration induced by syndecan-2, and syndecan-2-mediated cell migration was reduced when syntenin-1 expression diminished. However, syntenin-1-mediated migration enhancement was not noted in colon cancer cells transfected with a gene encoding a syndecan-2 mutant lacking the cytoplasmic domain. Furthermore, in line with the increase in cell migration, syntenin-1 mediated Rac activation stimulated by syndecan-2. Together, the data suggest that the cytoplasmic domain of syndecan-2 regulates colon cancer cell migration via interaction with syntenin-1."xsd:string |
| http://purl.uniprot.org/citations/21569759 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2011.04.135"xsd:string |
| http://purl.uniprot.org/citations/21569759 | http://purl.uniprot.org/core/author | "Choi S."xsd:string |
| http://purl.uniprot.org/citations/21569759 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/21569759 | http://purl.uniprot.org/core/author | "Hong E."xsd:string |
| http://purl.uniprot.org/citations/21569759 | http://purl.uniprot.org/core/author | "Lee H."xsd:string |
| http://purl.uniprot.org/citations/21569759 | http://purl.uniprot.org/core/author | "Choi Y."xsd:string |
| http://purl.uniprot.org/citations/21569759 | http://purl.uniprot.org/core/author | "Oh E.S."xsd:string |
| http://purl.uniprot.org/citations/21569759 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21569759 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/21569759 | http://purl.uniprot.org/core/pages | "148-153"xsd:string |
| http://purl.uniprot.org/citations/21569759 | http://purl.uniprot.org/core/title | "Syndecan-2 cytoplasmic domain regulates colon cancer cell migration via interaction with syntenin-1."xsd:string |
| http://purl.uniprot.org/citations/21569759 | http://purl.uniprot.org/core/volume | "409"xsd:string |
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