DESCRIBE <http://purl.uniprot.org/citations/21569768>

Subject	Predicate	Object
http://purl.uniprot.org/citations/21569768	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21569768	http://www.w3.org/2000/01/rdf-schema#comment	" Objective We have investigated the kinetics of α-galactosidase A and β-glucocerebrosidase deficient in Fabry and Gaucher diseases, respectively. Design and methods We have performed spectrofluorymetric measurements of the activity of enzymes using a derivative of 4-methylumbelliferone as a substrate and a human T-cell line as a source of enzymes. Results We have observed the substrate inhibition effect, which is related to temperature. Conclusions The diagnostic procedures for Fabry and Gaucher diseases used now in laboratory practice neglect temperature-dependent substrate inhibition, which may significantly reduce the sensitivity of enzyme activity determinations."xsd:string
http://purl.uniprot.org/citations/21569768	http://purl.org/dc/terms/identifier	"doi:10.1016/j.clinbiochem.2011.04.018"xsd:string
http://purl.uniprot.org/citations/21569768	http://purl.uniprot.org/core/author	"Czartoryska B."xsd:string
http://purl.uniprot.org/citations/21569768	http://purl.uniprot.org/core/author	"Chudy M."xsd:string
http://purl.uniprot.org/citations/21569768	http://purl.uniprot.org/core/author	"Ziolkowska K."xsd:string
http://purl.uniprot.org/citations/21569768	http://purl.uniprot.org/core/author	"Brzozka Z."xsd:string
http://purl.uniprot.org/citations/21569768	http://purl.uniprot.org/core/author	"Dybko A."xsd:string
http://purl.uniprot.org/citations/21569768	http://purl.uniprot.org/core/author	"Kwapiszewski R."xsd:string
http://purl.uniprot.org/citations/21569768	http://purl.uniprot.org/core/date	"2011"xsd:gYear
http://purl.uniprot.org/citations/21569768	http://purl.uniprot.org/core/name	"Clin Biochem"xsd:string
http://purl.uniprot.org/citations/21569768	http://purl.uniprot.org/core/pages	"941-943"xsd:string
http://purl.uniprot.org/citations/21569768	http://purl.uniprot.org/core/title	"Substrate inhibition of lysosomal hydrolases: alpha-Galactosidase A and beta-glucocerebrosidase."xsd:string
http://purl.uniprot.org/citations/21569768	http://purl.uniprot.org/core/volume	"44"xsd:string
http://purl.uniprot.org/citations/21569768	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/21569768
http://purl.uniprot.org/citations/21569768	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/21569768
http://purl.uniprot.org/uniprot/#_A0A0S3Q2A7-mappedCitation-21569768	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/21569768
http://purl.uniprot.org/uniprot/#_B4DLT5-mappedCitation-21569768	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/21569768
http://purl.uniprot.org/uniprot/#_P06280-mappedCitation-21569768	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/21569768
http://purl.uniprot.org/uniprot/#_Q53HF3-mappedCitation-21569768	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/21569768
http://purl.uniprot.org/uniprot/#_Q53Y83-mappedCitation-21569768	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/21569768
http://purl.uniprot.org/uniprot/Q53HF3	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/21569768
http://purl.uniprot.org/uniprot/B4DLT5	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/21569768
http://purl.uniprot.org/uniprot/A0A0S3Q2A7	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/21569768
http://purl.uniprot.org/uniprot/P06280	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/21569768