| http://purl.uniprot.org/citations/21573134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21573134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21573134 | http://www.w3.org/2000/01/rdf-schema#comment | "Elevation of the second messenger cGMP by nitric oxide (NO) activates the cGMP-dependent protein kinase PKG, which is key in regulating cardiovascular, intestinal, and neuronal functions in mammals. The NO-cGMP-PKG signaling pathway is also a major therapeutic target for cardiovascular and male reproductive diseases. Despite widespread effects of PKG activation, few molecular targets of PKG are known. We study how EGL-4, the Caenorhabditis elegans PKG ortholog, modulates foraging behavior and egg-laying and seeks the downstream effectors of EGL-4 activity. Using a combination of unbiased forward genetic screen and proteomic analysis, we have identified a conserved SAEG-1/SAEG-2/HDA-2 histone deacetylase complex that is specifically recruited by activated nuclear EGL-4. Gene expression profiling by microarrays revealed >40 genes that are sensitive to EGL-4 activity in a SAEG-1-dependent manner. We present evidence that EGL-4 controls egg laying via one of these genes, Y45F10C.2, which encodes a novel protein that is expressed exclusively in the uterine epithelium. Our results indicate that, in addition to cytoplasmic functions, active EGL-4/PKG acts in the nucleus via a conserved Class I histone deacetylase complex to regulate gene expression pertinent to behavioral and physiological responses to cGMP. We also identify transcriptional targets of EGL-4 that carry out discrete components of the physiological response."xsd:string |
| http://purl.uniprot.org/citations/21573134 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1002065"xsd:string |
| http://purl.uniprot.org/citations/21573134 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1002065"xsd:string |
| http://purl.uniprot.org/citations/21573134 | http://purl.uniprot.org/core/author | "Florens L."xsd:string |
| http://purl.uniprot.org/citations/21573134 | http://purl.uniprot.org/core/author | "Florens L."xsd:string |
| http://purl.uniprot.org/citations/21573134 | http://purl.uniprot.org/core/author | "Hao Y."xsd:string |
| http://purl.uniprot.org/citations/21573134 | http://purl.uniprot.org/core/author | "Hao Y."xsd:string |
| http://purl.uniprot.org/citations/21573134 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/21573134 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/21573134 | http://purl.uniprot.org/core/author | "Washburn M.P."xsd:string |
| http://purl.uniprot.org/citations/21573134 | http://purl.uniprot.org/core/author | "Washburn M.P."xsd:string |
| http://purl.uniprot.org/citations/21573134 | http://purl.uniprot.org/core/author | "Kannan K."xsd:string |
| http://purl.uniprot.org/citations/21573134 | http://purl.uniprot.org/core/author | "Kannan K."xsd:string |
| http://purl.uniprot.org/citations/21573134 | http://purl.uniprot.org/core/author | "Schaefer L."xsd:string |
| http://purl.uniprot.org/citations/21573134 | http://purl.uniprot.org/core/author | "Schaefer L."xsd:string |
| http://purl.uniprot.org/citations/21573134 | http://purl.uniprot.org/core/author | "Xu N."xsd:string |
| http://purl.uniprot.org/citations/21573134 | http://purl.uniprot.org/core/author | "Xu N."xsd:string |
| http://purl.uniprot.org/citations/21573134 | http://purl.uniprot.org/core/author | "Seidel C."xsd:string |
| http://purl.uniprot.org/citations/21573134 | http://purl.uniprot.org/core/author | "Seidel C."xsd:string |
| http://purl.uniprot.org/citations/21573134 | http://purl.uniprot.org/core/author | "Wiegraebe W."xsd:string |
| http://purl.uniprot.org/citations/21573134 | http://purl.uniprot.org/core/author | "Wiegraebe W."xsd:string |
| http://purl.uniprot.org/citations/21573134 | http://purl.uniprot.org/core/author | "Mak H.Y."xsd:string |
| http://purl.uniprot.org/citations/21573134 | http://purl.uniprot.org/core/author | "Mak H.Y."xsd:string |