Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/21573901http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21573901http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

MGb2, a mouse-derived monoclonal antibody specific to gastric carcinoma, was developed in our laboratory. Nevertheless, the potential role of MGb2-antigen/TRAK1 (MGb2-Ag/TRAK1) in colorectal cancer (CRC) is unclear. The aim of this study was to investigate the relationship between MGb2-Ag/TRAK1 expression and the clinicopathological characteristics of CRC. The potential utility of MGb2-Ag/TRAK1 expression as a prognostic indicator was also evaluated.

Methods

Immunohistochemistry and western blot were used to detect MGb2-Ag/TRAK1 expression in 140 CRC tissues. The relationship between MGb2-Ag/TRAK1 expression and clinicopathological characteristics and postoperative survival time was statistically analyzed.

Results

MGb2-Ag/TRAK1 expression in CRC tissues was significantly higher than in normal tissues and was positively correlated with tumor differentiation (p = 0.006), invasion (p = 0.049), and pathological stage (p = 0.032). There was no significant difference between MGb2-Ag/TRAK1 expression and the age or gender of the patient, lymphatic invasion, or distant metastasis (p = 0.586, 0.308, 0.910, and 0.068, respectively). The survival time of CRC patients with high expression of MGb2-Ag/TRAK1 was shorter than the survival time of patients with low MGb2-Ag/TRAK1 expression. Both univariate and multivariate analyses showed that tumor differentiation and MGb2-Ag/TRAK1 expression were two independent and prognostic factors for CRC (p < 0.001).

Conclusions

MGb2-Ag/TRAK1 may play an important role in the development of CRC and may be a valuable prognostic indicator of CRC."xsd:string
http://purl.uniprot.org/citations/21573901http://purl.org/dc/terms/identifier"doi:10.1007/s00384-011-1237-1"xsd:string
http://purl.uniprot.org/citations/21573901http://purl.uniprot.org/core/author"Chen S."xsd:string
http://purl.uniprot.org/citations/21573901http://purl.uniprot.org/core/author"Li H."xsd:string
http://purl.uniprot.org/citations/21573901http://purl.uniprot.org/core/author"Li K."xsd:string
http://purl.uniprot.org/citations/21573901http://purl.uniprot.org/core/author"Lu Y."xsd:string
http://purl.uniprot.org/citations/21573901http://purl.uniprot.org/core/author"Ren G."xsd:string
http://purl.uniprot.org/citations/21573901http://purl.uniprot.org/core/author"Nie Y."xsd:string
http://purl.uniprot.org/citations/21573901http://purl.uniprot.org/core/author"Zhang X."xsd:string
http://purl.uniprot.org/citations/21573901http://purl.uniprot.org/core/author"Xu B."xsd:string
http://purl.uniprot.org/citations/21573901http://purl.uniprot.org/core/author"Wang X."xsd:string
http://purl.uniprot.org/citations/21573901http://purl.uniprot.org/core/author"Zhou Y."xsd:string
http://purl.uniprot.org/citations/21573901http://purl.uniprot.org/core/author"Zhao Q."xsd:string
http://purl.uniprot.org/citations/21573901http://purl.uniprot.org/core/author"Wang T."xsd:string
http://purl.uniprot.org/citations/21573901http://purl.uniprot.org/core/author"An Y."xsd:string
http://purl.uniprot.org/citations/21573901http://purl.uniprot.org/core/author"Tian Q."xsd:string
http://purl.uniprot.org/citations/21573901http://purl.uniprot.org/core/author"Su T."xsd:string
http://purl.uniprot.org/citations/21573901http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21573901http://purl.uniprot.org/core/name"Int J Colorectal Dis"xsd:string
http://purl.uniprot.org/citations/21573901http://purl.uniprot.org/core/pages"1397-1404"xsd:string
http://purl.uniprot.org/citations/21573901http://purl.uniprot.org/core/title"Elevated expression of MGb2-Ag/TRAK1 is correlated with poor prognosis in patients with colorectal cancer."xsd:string
http://purl.uniprot.org/citations/21573901http://purl.uniprot.org/core/volume"26"xsd:string
http://purl.uniprot.org/citations/21573901http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21573901
http://purl.uniprot.org/citations/21573901http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/21573901
▶