http://purl.uniprot.org/citations/21573905 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/21573905 | http://www.w3.org/2000/01/rdf-schema#comment | "Aims/hypothesisSeveral genome-wide linkage studies have shown an association between diabetic nephropathy and a locus on chromosome 18q harbouring two carnosinase genes, CNDP1 and CNDP2. Carnosinase degrades carnosine (β-alanyl-L-histidine), which has been ascribed a renal protective effect as a scavenger of reactive oxygen species. We investigated the putative associations of genetic variants in CNDP1 and CNDP2 with diabetic nephropathy (defined either as micro- or macroalbuminuria) and estimated GFR in type 2 diabetic patients from Sweden.MethodsWe genotyped nine single nucleotide polymorphisms (SNPs) and one trinucleotide repeat polymorphism (D18S880, five to seven leucine repeats) in CNDP1 and CNDP2 in a case-control set-up including 4,888 unrelated type 2 diabetic patients (with and without nephropathy) from Sweden (Scania Diabetes Registry).ResultsTwo SNPs, rs2346061 in CNDP1 and rs7577 in CNDP2, were associated with an increased risk of diabetic nephropathy (rs2346061 p = 5.07 × 10(-4); rs7577 p = 0.021). The latter was also associated with estimated GFR (β = -0.037, p = 0.014), particularly in women. A haplotype including these SNPs (C-C-G) was associated with a threefold increased risk of diabetic nephropathy (OR 2.98, 95% CI 2.43-3.67, p < 0.0001).Conclusions/interpretationThese data suggest that common variants in CNDP1 and CNDP2 play a role in susceptibility to kidney disease in patients with type 2 diabetes."xsd:string |
http://purl.uniprot.org/citations/21573905 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00125-011-2178-5"xsd:string |
http://purl.uniprot.org/citations/21573905 | http://purl.uniprot.org/core/author | "Groop L.C."xsd:string |
http://purl.uniprot.org/citations/21573905 | http://purl.uniprot.org/core/author | "Ahluwalia T.S."xsd:string |
http://purl.uniprot.org/citations/21573905 | http://purl.uniprot.org/core/author | "Lindholm E."xsd:string |
http://purl.uniprot.org/citations/21573905 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
http://purl.uniprot.org/citations/21573905 | http://purl.uniprot.org/core/name | "Diabetologia"xsd:string |
http://purl.uniprot.org/citations/21573905 | http://purl.uniprot.org/core/pages | "2295-2302"xsd:string |
http://purl.uniprot.org/citations/21573905 | http://purl.uniprot.org/core/title | "Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes."xsd:string |
http://purl.uniprot.org/citations/21573905 | http://purl.uniprot.org/core/volume | "54"xsd:string |
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