| http://purl.uniprot.org/citations/21575866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21575866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21575866 | http://www.w3.org/2000/01/rdf-schema#comment | "Anaplastic lymphoma kinase (ALK) is a tyrosine kinase that is constitutively activated in certain cancers, following gene alterations such as chromosomal translocation, amplification, or point mutation. Here, we identified CH5424802, a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK, such as nonsmall cell lung cancer (NSCLC) cells expressing EML4-ALK fusion and anaplastic large-cell lymphoma (ALCL) cells expressing NPM-ALK fusion in vitro and in vivo. CH5424802 inhibited ALK L1196M, which corresponds to the gatekeeper mutation conferring common resistance to kinase inhibitors, and blocked EML4-ALK L1196M-driven cell growth. Our results support the potential for clinical evaluation of CH5424802 for the treatment of patients with ALK-driven tumors."xsd:string |
| http://purl.uniprot.org/citations/21575866 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2011.04.004"xsd:string |
| http://purl.uniprot.org/citations/21575866 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2011.04.004"xsd:string |
| http://purl.uniprot.org/citations/21575866 | http://purl.uniprot.org/core/author | "Kodama T."xsd:string |
| http://purl.uniprot.org/citations/21575866 | http://purl.uniprot.org/core/author | "Kodama T."xsd:string |
| http://purl.uniprot.org/citations/21575866 | http://purl.uniprot.org/core/author | "Kobayashi T."xsd:string |
| http://purl.uniprot.org/citations/21575866 | http://purl.uniprot.org/core/author | "Kobayashi T."xsd:string |
| http://purl.uniprot.org/citations/21575866 | http://purl.uniprot.org/core/author | "Ishii N."xsd:string |
| http://purl.uniprot.org/citations/21575866 | http://purl.uniprot.org/core/author | "Ishii N."xsd:string |
| http://purl.uniprot.org/citations/21575866 | http://purl.uniprot.org/core/author | "Sakamoto H."xsd:string |
| http://purl.uniprot.org/citations/21575866 | http://purl.uniprot.org/core/author | "Sakamoto H."xsd:string |
| http://purl.uniprot.org/citations/21575866 | http://purl.uniprot.org/core/author | "Aoki Y."xsd:string |
| http://purl.uniprot.org/citations/21575866 | http://purl.uniprot.org/core/author | "Aoki Y."xsd:string |
| http://purl.uniprot.org/citations/21575866 | http://purl.uniprot.org/core/author | "Fukami T.A."xsd:string |
| http://purl.uniprot.org/citations/21575866 | http://purl.uniprot.org/core/author | "Fukami T.A."xsd:string |
| http://purl.uniprot.org/citations/21575866 | http://purl.uniprot.org/core/author | "Hiroshima S."xsd:string |
| http://purl.uniprot.org/citations/21575866 | http://purl.uniprot.org/core/author | "Hiroshima S."xsd:string |
| http://purl.uniprot.org/citations/21575866 | http://purl.uniprot.org/core/author | "Oikawa N."xsd:string |
| http://purl.uniprot.org/citations/21575866 | http://purl.uniprot.org/core/author | "Oikawa N."xsd:string |
| http://purl.uniprot.org/citations/21575866 | http://purl.uniprot.org/core/author | "Tsukaguchi T."xsd:string |
| http://purl.uniprot.org/citations/21575866 | http://purl.uniprot.org/core/author | "Tsukaguchi T."xsd:string |
| http://purl.uniprot.org/citations/21575866 | http://purl.uniprot.org/core/author | "Tsukuda T."xsd:string |
| http://purl.uniprot.org/citations/21575866 | http://purl.uniprot.org/core/author | "Tsukuda T."xsd:string |