| http://purl.uniprot.org/citations/21576457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21576457 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuronal populations display conspicuous variability in their size among individuals, but the genetic sources of this variation are largely undefined. We demonstrate a large and highly heritable variation in neuron number within the mouse retina, affecting a critical population of interneurons, the horizontal cells. Variation in the size of this population maps to the distal end of chromosome (Chr) 13, a region homologous to human Chr 5q11.1-11.2. This region contains two genes known to modulate retinal cell number. Using conditional knock-out mice, we demonstrate that one of these genes, the LIM homeodomain gene Islet-1 (Isl1), plays a role in regulating horizontal cell number. Genetic differences in Isl1 expression are high during the period of horizontal cell production, and cis-regulation of Isl1 expression within the retina is demonstrated directly. We identify a single nucleotide polymorphism in the 5' UTR of Isl1 that creates an E-box sequence as a candidate causal variant contributing to this variation in horizontal cell number."xsd:string |
| http://purl.uniprot.org/citations/21576457 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1103253108"xsd:string |
| http://purl.uniprot.org/citations/21576457 | http://purl.uniprot.org/core/author | "Gan L."xsd:string |
| http://purl.uniprot.org/citations/21576457 | http://purl.uniprot.org/core/author | "Williams R.W."xsd:string |
| http://purl.uniprot.org/citations/21576457 | http://purl.uniprot.org/core/author | "Ding Q."xsd:string |
| http://purl.uniprot.org/citations/21576457 | http://purl.uniprot.org/core/author | "Reese B.E."xsd:string |
| http://purl.uniprot.org/citations/21576457 | http://purl.uniprot.org/core/author | "Ciobanu D.C."xsd:string |
| http://purl.uniprot.org/citations/21576457 | http://purl.uniprot.org/core/author | "Whitney I.E."xsd:string |
| http://purl.uniprot.org/citations/21576457 | http://purl.uniprot.org/core/author | "Elshatory Y."xsd:string |
| http://purl.uniprot.org/citations/21576457 | http://purl.uniprot.org/core/author | "Raven M.A."xsd:string |
| http://purl.uniprot.org/citations/21576457 | http://purl.uniprot.org/core/author | "Poche R.A."xsd:string |
| http://purl.uniprot.org/citations/21576457 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21576457 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/21576457 | http://purl.uniprot.org/core/pages | "9697-9702"xsd:string |
| http://purl.uniprot.org/citations/21576457 | http://purl.uniprot.org/core/title | "Genetic modulation of horizontal cell number in the mouse retina."xsd:string |
| http://purl.uniprot.org/citations/21576457 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/21576457 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21576457 |
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