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http://purl.uniprot.org/citations/21586896http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21586896http://www.w3.org/2000/01/rdf-schema#comment"

Aim

The aims of the study were to understand the association between insulin-like factor 3 (INSL3) and functional ovarian hyperandrogenism (FOH) in PCOS and the regulatory role played by LH.

Subjects and methods

Fifteen PCOS women were classified as FOH (FOH-PCOS, no.=8) and non-FOH (NFOH-PCOS, no.=7) according to the response of 17OH-progesterone to buserelin (a GnRH analogue) with respect to 15 controls. FOH-PCOS and NFOH-PCOS were compared for basal INSL3 levels. In addition, the effect of buserelin on INSL3 concentrations and the relationship between basal and buserelin-stimulated LH and 17OH-progesterone and INSL3 were evaluated.

Results

Basal INSL3 levels were higher in FOH-PCOS than NFOH-PCOS (p=0.001) and controls (p=0.001), whereas they did not differ between NFOHPCOS and controls. In addition, FOH-PCOS had a higher response of LH to buserelin with respect to NFOH-PCOS. Within all PCOS women the levels of INSL3 positively correlated with free testosterone (p=0.022) and negatively with SHBG (r= p=0.031). Moreover, positive correlations with the absolute increase of 17OH-progesterone (p<0.001) and with the LH area under the curve (p=0.001) after buserelin administration were found. In the multiple regression analysis INSL3 persisted significantly correlated only with 17OH-progesterone response to buserelin. Finally, INSL3 was not significantly modified after buserelin administration either in FOHPCOS or in NFOH-PCOS.

Conclusions

These data suggest that INSL3 is related to FOH in PCOS women, but this association seems not to be mediated by LH, further reinforcing the concept that a pathophysiological heterogeneity for ovarian hyperandrogenism in PCOS exists."xsd:string
http://purl.uniprot.org/citations/21586896http://purl.org/dc/terms/identifier"doi:10.3275/7726"xsd:string
http://purl.uniprot.org/citations/21586896http://purl.uniprot.org/core/author"Fanelli F."xsd:string
http://purl.uniprot.org/citations/21586896http://purl.uniprot.org/core/author"Pagotto U."xsd:string
http://purl.uniprot.org/citations/21586896http://purl.uniprot.org/core/author"Pasquali R."xsd:string
http://purl.uniprot.org/citations/21586896http://purl.uniprot.org/core/author"Gambineri A."xsd:string
http://purl.uniprot.org/citations/21586896http://purl.uniprot.org/core/author"Patton L."xsd:string
http://purl.uniprot.org/citations/21586896http://purl.uniprot.org/core/author"Ciampaglia W."xsd:string
http://purl.uniprot.org/citations/21586896http://purl.uniprot.org/core/author"Cognigni G.E."xsd:string
http://purl.uniprot.org/citations/21586896http://purl.uniprot.org/core/author"Prontera O."xsd:string
http://purl.uniprot.org/citations/21586896http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21586896http://purl.uniprot.org/core/name"J Endocrinol Invest"xsd:string
http://purl.uniprot.org/citations/21586896http://purl.uniprot.org/core/pages"685-691"xsd:string
http://purl.uniprot.org/citations/21586896http://purl.uniprot.org/core/title"Basal insulin-like factor 3 levels predict functional ovarian hyperandrogenism in the polycystic ovary syndrome."xsd:string
http://purl.uniprot.org/citations/21586896http://purl.uniprot.org/core/volume"34"xsd:string
http://purl.uniprot.org/citations/21586896http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21586896
http://purl.uniprot.org/citations/21586896http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/21586896
http://purl.uniprot.org/uniprot/#_P51460-mappedCitation-21586896http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21586896
http://purl.uniprot.org/uniprot/P51460http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/21586896