| http://purl.uniprot.org/citations/21593251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21593251 | http://www.w3.org/2000/01/rdf-schema#comment | "Programmed cell death, or apoptosis, is one of the fates of the medial edge epithelium (MEE) during palatal fusion. Transforming growth factor β (Tgf-β) signaling (such as Tgf-β3) is required for the disappearance of the MEE, but the relationship between Tgf-β3 and apoptosis remains unclear. Here we show that the Fas ligand (FasL)-Fas-Caspase extrinsic apoptosis pathway functions during palatal fusion in wild-type mice, but is not detectable in mice lacking Tgf-β3 (Tgf-β3 (-/-) ) or Tgfβr2 in the MEE (K14-Cre;Tgfbr2 (fl/fl)). Inhibition of the FasL-Fas system results in persistence of the midline epithelial seam (MES) and inhibition of caspase activity during palatal organ culture. Moreover, ectopic FasL protein induces apoptosis in MES of K14-Cre;Tgfbr2 (fl/fl) mice. Thus, we conclude that the FasL-Fas-caspase extrinsic apoptosis pathway is regulated by the Tgf-β3 signaling cascade and is essential for palatal fusion during craniofacial development."xsd:string |
| http://purl.uniprot.org/citations/21593251 | http://purl.org/dc/terms/identifier | "doi:10.1177/0022034511408613"xsd:string |
| http://purl.uniprot.org/citations/21593251 | http://purl.uniprot.org/core/author | "Huang X."xsd:string |
| http://purl.uniprot.org/citations/21593251 | http://purl.uniprot.org/core/author | "Chai Y."xsd:string |
| http://purl.uniprot.org/citations/21593251 | http://purl.uniprot.org/core/author | "Yokota T."xsd:string |
| http://purl.uniprot.org/citations/21593251 | http://purl.uniprot.org/core/author | "Iwata J."xsd:string |
| http://purl.uniprot.org/citations/21593251 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21593251 | http://purl.uniprot.org/core/name | "J Dent Res"xsd:string |
| http://purl.uniprot.org/citations/21593251 | http://purl.uniprot.org/core/pages | "981-987"xsd:string |
| http://purl.uniprot.org/citations/21593251 | http://purl.uniprot.org/core/title | "Tgf-beta-mediated FasL-Fas-Caspase pathway is crucial during palatogenesis."xsd:string |
| http://purl.uniprot.org/citations/21593251 | http://purl.uniprot.org/core/volume | "90"xsd:string |
| http://purl.uniprot.org/citations/21593251 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21593251 |
| http://purl.uniprot.org/citations/21593251 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21593251 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXU9-mappedCitation-21593251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21593251 |
| http://purl.uniprot.org/uniprot/#_A0A494BBE8-mappedCitation-21593251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21593251 |
| http://purl.uniprot.org/uniprot/#_A0A494BBP5-mappedCitation-21593251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21593251 |
| http://purl.uniprot.org/uniprot/#_A1Y9B0-mappedCitation-21593251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21593251 |
| http://purl.uniprot.org/uniprot/#_A1Y9B2-mappedCitation-21593251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21593251 |
| http://purl.uniprot.org/uniprot/#_Q62312-mappedCitation-21593251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21593251 |
| http://purl.uniprot.org/uniprot/#_Q7TMV9-mappedCitation-21593251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21593251 |
| http://purl.uniprot.org/uniprot/#_P27090-mappedCitation-21593251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21593251 |
| http://purl.uniprot.org/uniprot/#_P41047-mappedCitation-21593251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21593251 |
| http://purl.uniprot.org/uniprot/#_Q3TTJ9-mappedCitation-21593251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21593251 |
| http://purl.uniprot.org/uniprot/#_Q921T1-mappedCitation-21593251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21593251 |