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| http://purl.uniprot.org/citations/21593388 | http://www.w3.org/2000/01/rdf-schema#comment | "Postsynaptic intracellular Ca(2+) concentration ([Ca(2+)](i)) has been proposed to play an important role in both synaptic plasticity and synaptic homeostasis. In particular, postsynaptic Ca(2+) signals can alter synaptic efficacy by influencing transmitter release, receptor sensitivity, and protein synthesis. We examined the postsynaptic Ca(2+) transients at the Drosophila larval neuromuscular junction (NMJ) by injecting the muscle fibers with Ca(2+) indicators rhod-2 and Oregon Green BAPTA-1 (OGB-1) and then monitoring their increased fluorescence during synaptic activity. We observed discrete postsynaptic Ca(2+) transients along the NMJ during single action potentials (APs) and quantal Ca(2+) transients produced by spontaneous transmitter release. Most of the evoked Ca(2+) transients resulted from the release of one or two quanta of transmitter and occurred largely at synaptic boutons. The magnitude of the Ca(2+) signals was correlated with synaptic efficacy; the Is terminals, which produce larger excitatory postsynaptic potentials (EPSPs) and have a greater quantal size than Ib terminals, produced a larger Ca(2+) signal per terminal length and larger quantal Ca(2+) signals than the Ib terminals. During a train of APs, the postsynaptic Ca(2+) signal increased but remained localized to the postsynaptic membrane. In addition, we showed that the plasma membrane Ca(2+)-ATPase (PMCA) played a role in extruding Ca(2+) from the postsynaptic region of the muscle. Drosophila melanogaster has a single PMCA gene, predicted to give rise to various isoforms by alternative splicing. Using RT-PCR, we detected the expression of multiple transcripts in muscle and nervous tissues; the physiological significance of the same is yet to be determined."xsd:string |
| http://purl.uniprot.org/citations/21593388 | http://purl.org/dc/terms/identifier | "doi:10.1152/jn.00045.2011"xsd:string |
| http://purl.uniprot.org/citations/21593388 | http://purl.uniprot.org/core/author | "Lnenicka G.A."xsd:string |
| http://purl.uniprot.org/citations/21593388 | http://purl.uniprot.org/core/author | "Desai S.A."xsd:string |
| http://purl.uniprot.org/citations/21593388 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21593388 | http://purl.uniprot.org/core/name | "J Neurophysiol"xsd:string |
| http://purl.uniprot.org/citations/21593388 | http://purl.uniprot.org/core/pages | "710-721"xsd:string |
| http://purl.uniprot.org/citations/21593388 | http://purl.uniprot.org/core/title | "Characterization of postsynaptic Ca2+ signals at the Drosophila larval NMJ."xsd:string |
| http://purl.uniprot.org/citations/21593388 | http://purl.uniprot.org/core/volume | "106"xsd:string |
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