| http://purl.uniprot.org/citations/21593413 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21593413 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-21 is a pleiotropic type 1 cytokine that shares the common cytokine receptor γ-chain, γ(c), with IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is most homologous to IL-2. These cytokines are encoded by adjacent genes, but they are functionally distinct. Whereas IL-2 promotes development of regulatory T cells and confers protection from autoimmune disease, IL-21 promotes differentiation of Th17 cells and is implicated in several autoimmune diseases, including type 1 diabetes and systemic lupus erythematosus. However, the roles of IL-21 and IL-2 in CNS autoimmune diseases such as multiple sclerosis and uveitis have been controversial. Here, we generated Il21-mCherry/Il2-emGFP dual-reporter transgenic mice and showed that development of experimental autoimmune uveitis (EAU) correlated with the presence of T cells coexpressing IL-21 and IL-2 into the retina. Furthermore, Il21r(-/-) mice were more resistant to EAU development than wild-type mice, and adoptive transfer of Il21r(-/-) T cells induced much less severe EAU, underscoring the need for IL-21 in the development of this disease and suggesting that blocking IL-21/γ(c)-signaling pathways may provide a means for controlling CNS auto-inflammatory diseases."xsd:string |
| http://purl.uniprot.org/citations/21593413 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1018182108"xsd:string |
| http://purl.uniprot.org/citations/21593413 | http://purl.uniprot.org/core/author | "Liao W."xsd:string |
| http://purl.uniprot.org/citations/21593413 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/21593413 | http://purl.uniprot.org/core/author | "Leonard W.J."xsd:string |
| http://purl.uniprot.org/citations/21593413 | http://purl.uniprot.org/core/author | "Kim H.P."xsd:string |
| http://purl.uniprot.org/citations/21593413 | http://purl.uniprot.org/core/author | "Yu C.R."xsd:string |
| http://purl.uniprot.org/citations/21593413 | http://purl.uniprot.org/core/author | "Egwuagu C.E."xsd:string |
| http://purl.uniprot.org/citations/21593413 | http://purl.uniprot.org/core/author | "Telford W.G."xsd:string |
| http://purl.uniprot.org/citations/21593413 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21593413 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/21593413 | http://purl.uniprot.org/core/pages | "9542-9547"xsd:string |
| http://purl.uniprot.org/citations/21593413 | http://purl.uniprot.org/core/title | "Key role for IL-21 in experimental autoimmune uveitis."xsd:string |
| http://purl.uniprot.org/citations/21593413 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/21593413 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21593413 |
| http://purl.uniprot.org/citations/21593413 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21593413 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP02-mappedCitation-21593413 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21593413 |
| http://purl.uniprot.org/uniprot/#_A5J0L5-mappedCitation-21593413 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21593413 |
| http://purl.uniprot.org/uniprot/#_E9PX58-mappedCitation-21593413 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21593413 |
| http://purl.uniprot.org/uniprot/#_Q0PGS4-mappedCitation-21593413 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21593413 |
| http://purl.uniprot.org/uniprot/#_Q91Y49-mappedCitation-21593413 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21593413 |
| http://purl.uniprot.org/uniprot/#_Q546X1-mappedCitation-21593413 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21593413 |
| http://purl.uniprot.org/uniprot/#_Q8BHA4-mappedCitation-21593413 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21593413 |
| http://purl.uniprot.org/uniprot/#_P04351-mappedCitation-21593413 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21593413 |