| http://purl.uniprot.org/citations/21593558 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21593558 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21593558 | http://www.w3.org/2000/01/rdf-schema#comment | "Alzheimer's disease (AD) is characterized by disrupted metabolism of the amyloid-β protein precursor (AβPP) and deposition of a byproduct, the amyloid-β (Aβ) peptide, into plaques. AD is also genetically linked to the gene for apolipoprotein E (apoE). We have identified a novel apoE-binding protein (TMCC2) that also forms a complex with AβPP. TMCC2 is a neuronal, predominantly ER-localized, protein that co-migrated with AβPP during native gel electrophoresis of rat brain extracts, and co-immunoprecipitated with AβPP from transfected human cell lysates. TMCC2 bound apoE in an isoform-specific manner in vitro and co-immunoprecipitated with apoE from cell lysates. Co-expression of apoE and TMCC2 stimulated Aβ production from the "Swedish" variant of AβPP (K595 M/N596L) by up to 1.5-fold (p < 0.05), and also from the 99-amino acid C-terminal fragment of AβPP (AβPP-C99) that is the direct precursor to Aβ by 1.5-to 2-fold (p < 0.0005), this effect was greater with apoE4 than apoE3 (p = 0.02); both apoE3 and apoE4 stimulated a greater increase in Aβ1-42 than Aβ1-40 production from AβPP-C99 in the presence of TMCC2. The interaction between TMCC2 and apoE may therefore contribute to disrupted AβPP metabolism and altered Aβ production, as observed in AD."xsd:string |
| http://purl.uniprot.org/citations/21593558 | http://purl.org/dc/terms/identifier | "doi:10.3233/jad-2011-102115"xsd:string |
| http://purl.uniprot.org/citations/21593558 | http://purl.org/dc/terms/identifier | "doi:10.3233/jad-2011-102115"xsd:string |
| http://purl.uniprot.org/citations/21593558 | http://purl.uniprot.org/core/author | "Sainz-Fuertes R."xsd:string |
| http://purl.uniprot.org/citations/21593558 | http://purl.uniprot.org/core/author | "Sainz-Fuertes R."xsd:string |
| http://purl.uniprot.org/citations/21593558 | http://purl.uniprot.org/core/author | "Lovestone S."xsd:string |
| http://purl.uniprot.org/citations/21593558 | http://purl.uniprot.org/core/author | "Lovestone S."xsd:string |
| http://purl.uniprot.org/citations/21593558 | http://purl.uniprot.org/core/author | "Hopkins P.C."xsd:string |
| http://purl.uniprot.org/citations/21593558 | http://purl.uniprot.org/core/author | "Hopkins P.C."xsd:string |
| http://purl.uniprot.org/citations/21593558 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21593558 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21593558 | http://purl.uniprot.org/core/name | "J. Alzheimers Dis."xsd:string |
| http://purl.uniprot.org/citations/21593558 | http://purl.uniprot.org/core/name | "J. Alzheimers Dis."xsd:string |
| http://purl.uniprot.org/citations/21593558 | http://purl.uniprot.org/core/pages | "239-253"xsd:string |
| http://purl.uniprot.org/citations/21593558 | http://purl.uniprot.org/core/pages | "239-253"xsd:string |
| http://purl.uniprot.org/citations/21593558 | http://purl.uniprot.org/core/title | "The impact of a novel apolipoprotein E and amyloid-beta protein precursor-interacting protein on the production of amyloid-beta."xsd:string |
| http://purl.uniprot.org/citations/21593558 | http://purl.uniprot.org/core/title | "The impact of a novel apolipoprotein E and amyloid-beta protein precursor-interacting protein on the production of amyloid-beta."xsd:string |
| http://purl.uniprot.org/citations/21593558 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/21593558 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/21593558 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21593558 |
| http://purl.uniprot.org/citations/21593558 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21593558 |
| http://purl.uniprot.org/citations/21593558 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21593558 |
| http://purl.uniprot.org/citations/21593558 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21593558 |