| http://purl.uniprot.org/citations/21593590 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21593590 | http://www.w3.org/2000/01/rdf-schema#comment | "Zinc finger protein 521 (EHZF/ZNF521) is a multi-functional transcription co-factor containing 30 zinc fingers and an amino-terminal motif that binds to the nucleosome remodelling and histone deacetylase (NuRD) complex. ZNF521 is believed to be a relevant player in the regulation of the homeostasis of the hematopoietic stem/progenitor cell compartment, however the underlying molecular mechanisms are still largely unknown. Here, we show that this protein plays an important role in the control of B-cell development by inhibiting the activity of early B-cell factor-1 (EBF1), a master factor in B-lineage specification. In particular, our data demonstrate that: (1) ZNF521 binds to EBF1 via its carboxyl-terminal portion and this interaction is required for EBF1 inhibition; (2) NuRD complex recruitment by ZNF521 is not essential for the inhibition of transactivation of EBF1-dependent promoters; (3) ZNF521 represses EBF1 target genes in a human B-lymphoid molecular context; and (4) RNAi-mediated silencing of ZNF521/Zfp521 in primary human and murine hematopoietic progenitors strongly enhances the generation of B-lymphocytes in vitro. Taken together, our data indicate that ZNF521 can antagonize B-cell development and lend support to the notion that it may contribute to conserve the multipotency of primitive lympho-myeloid progenitors by preventing or delaying their EBF1-driven commitment toward the B-cell lineage."xsd:string |
| http://purl.uniprot.org/citations/21593590 | http://purl.org/dc/terms/identifier | "doi:10.4161/cc.10.13.16045"xsd:string |
| http://purl.uniprot.org/citations/21593590 | http://purl.uniprot.org/core/author | "Schuringa J.J."xsd:string |
| http://purl.uniprot.org/citations/21593590 | http://purl.uniprot.org/core/author | "Grieco M."xsd:string |
| http://purl.uniprot.org/citations/21593590 | http://purl.uniprot.org/core/author | "Agosti V."xsd:string |
| http://purl.uniprot.org/citations/21593590 | http://purl.uniprot.org/core/author | "Amodio N."xsd:string |
| http://purl.uniprot.org/citations/21593590 | http://purl.uniprot.org/core/author | "Bond H.M."xsd:string |
| http://purl.uniprot.org/citations/21593590 | http://purl.uniprot.org/core/author | "Mesuraca M."xsd:string |
| http://purl.uniprot.org/citations/21593590 | http://purl.uniprot.org/core/author | "Moore M.A."xsd:string |
| http://purl.uniprot.org/citations/21593590 | http://purl.uniprot.org/core/author | "Morrone G."xsd:string |
| http://purl.uniprot.org/citations/21593590 | http://purl.uniprot.org/core/author | "Spina R."xsd:string |
| http://purl.uniprot.org/citations/21593590 | http://purl.uniprot.org/core/author | "Mega T."xsd:string |
| http://purl.uniprot.org/citations/21593590 | http://purl.uniprot.org/core/author | "Horton S.J."xsd:string |
| http://purl.uniprot.org/citations/21593590 | http://purl.uniprot.org/core/author | "Pelaggi D."xsd:string |
| http://purl.uniprot.org/citations/21593590 | http://purl.uniprot.org/core/author | "Chiarella E."xsd:string |
| http://purl.uniprot.org/citations/21593590 | http://purl.uniprot.org/core/author | "Lupia M."xsd:string |
| http://purl.uniprot.org/citations/21593590 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21593590 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/21593590 | http://purl.uniprot.org/core/pages | "2129-2139"xsd:string |
| http://purl.uniprot.org/citations/21593590 | http://purl.uniprot.org/core/title | "Zinc finger protein 521 antagonizes early B-cell factor 1 and modulates the B-lymphoid differentiation of primary hematopoietic progenitors."xsd:string |
| http://purl.uniprot.org/citations/21593590 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/21593590 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21593590 |
| http://purl.uniprot.org/citations/21593590 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21593590 |
| http://purl.uniprot.org/uniprot/#_A8K0Z7-mappedCitation-21593590 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21593590 |