| http://purl.uniprot.org/citations/21598828 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21598828 | http://www.w3.org/2000/01/rdf-schema#comment | "This study aimed to investigate HLA-DRB1 alleles in rheumatoid arthritis (RA) patients from Tunisia and to examine the effect of these alleles on disease severity. HLA-DRBI alleles and sub-typing of DRBI*04 and *01 were determined in 90 patients and 100 healthy controls, by PCR-SSP. HLA-DRB1*04 was significantly higher in patients (51.1%) than in controls (27%) [OR=2.83, p=0.00066]. DRBJ*0405 was found to be the unique DR4 allele associated with RA (28.88% vs 6%) [OR=6.36, p=0.000059]. A significant decrease in the frequency of HLA-DRB1*0701 was observed in RA patients (16.66%) compared to controls (36%) [p=0.0026]. However, the frequency of patients carrying the shared epitope (SE) QRRAA, was slightly increased compared with controls (37.8% vs 23%) [OR=2.03, p=0.039]. We found that the presence of rheumatoid factor, HLA-DR4 and HLA-DRBI*0405 were not significantly associated with bone erosions or the presence of extra-joint involvement. In our population, the SE (QRRAA) expressed in DRBI*04 alleles is related to the susceptibility to RA but it is not involved in RA severity in Tunisia, while DRBI*0701 might protect against this disease."xsd:string |
| http://purl.uniprot.org/citations/21598828 | http://purl.uniprot.org/core/author | "Zouari R."xsd:string |
| http://purl.uniprot.org/citations/21598828 | http://purl.uniprot.org/core/author | "Makhlouf M."xsd:string |
| http://purl.uniprot.org/citations/21598828 | http://purl.uniprot.org/core/author | "Aouadi H."xsd:string |
| http://purl.uniprot.org/citations/21598828 | http://purl.uniprot.org/core/author | "Ayed K."xsd:string |
| http://purl.uniprot.org/citations/21598828 | http://purl.uniprot.org/core/author | "Ben Abdallah T."xsd:string |
| http://purl.uniprot.org/citations/21598828 | http://purl.uniprot.org/core/author | "Sfar I."xsd:string |
| http://purl.uniprot.org/citations/21598828 | http://purl.uniprot.org/core/author | "Jendoubi-Ayed S."xsd:string |
| http://purl.uniprot.org/citations/21598828 | http://purl.uniprot.org/core/author | "Bardi R."xsd:string |
| http://purl.uniprot.org/citations/21598828 | http://purl.uniprot.org/core/author | "Abdelmoula L."xsd:string |
| http://purl.uniprot.org/citations/21598828 | http://purl.uniprot.org/core/author | "Dhaouadi T."xsd:string |
| http://purl.uniprot.org/citations/21598828 | http://purl.uniprot.org/core/author | "Lakhoua-Gorgi Y."xsd:string |
| http://purl.uniprot.org/citations/21598828 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21598828 | http://purl.uniprot.org/core/name | "Arch Inst Pasteur Tunis"xsd:string |
| http://purl.uniprot.org/citations/21598828 | http://purl.uniprot.org/core/pages | "53-59"xsd:string |
| http://purl.uniprot.org/citations/21598828 | http://purl.uniprot.org/core/title | "Association of specific amino acid sequence (QRRAA) of HLA-DRB1*0405 with rheumatoid arthritis in a Tunisian population."xsd:string |
| http://purl.uniprot.org/citations/21598828 | http://purl.uniprot.org/core/volume | "87"xsd:string |
| http://purl.uniprot.org/citations/21598828 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21598828 |
| http://purl.uniprot.org/citations/21598828 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21598828 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-21598828 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21598828 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-21598828 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21598828 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-21598828 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21598828 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-21598828 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21598828 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD60-mappedCitation-21598828 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21598828 |