| http://purl.uniprot.org/citations/21606371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21606371 | http://www.w3.org/2000/01/rdf-schema#comment | "Endogenous and pharmacologic glucocorticoids (GCs) limit inflammatory cascades initiated by Toll-like receptor (TLR) activation. A long-standing clinical observation has been the delay between GC administration and the manifestation of GC's anti-inflammatory actions. We hypothesized that the GCs would have inhibitory effects that target late temporal pathways that propagate proinflammatory signals. Here we interrogated signal transducer and activator of transcription 1 (STAT1) regulation by GC and its consequences for cytokine production during activation of macrophages with TLR-specific ligands. We found that robust STAT1 activation does not occur until 2-3 h after TLR engagement, and that GC suppression of STAT1 phosphorylation first manifests at this time. GC attenuates TLR4-mediated STAT1 activation only through induction of suppressor of cytokine signaling 1 (SOCS1), which increases throughout the 6-h period after treatment. Inhibition of TLR3-mediated STAT1 activation occurs via two mechanisms, impairment of type I IFN secretion and induction of SOCS1. Our data show that SOCS1 and type I interferons are critical GC targets for regulating STAT1 activity and may account for overall GC effectiveness in inflammation suppression in the clinically relevant time frame."xsd:string |
| http://purl.uniprot.org/citations/21606371 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1017296108"xsd:string |
| http://purl.uniprot.org/citations/21606371 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/21606371 | http://purl.uniprot.org/core/author | "Bhattacharyya S."xsd:string |
| http://purl.uniprot.org/citations/21606371 | http://purl.uniprot.org/core/author | "Muglia L.J."xsd:string |
| http://purl.uniprot.org/citations/21606371 | http://purl.uniprot.org/core/author | "Kay T.W."xsd:string |
| http://purl.uniprot.org/citations/21606371 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21606371 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/21606371 | http://purl.uniprot.org/core/pages | "9554-9559"xsd:string |
| http://purl.uniprot.org/citations/21606371 | http://purl.uniprot.org/core/title | "Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation."xsd:string |
| http://purl.uniprot.org/citations/21606371 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/21606371 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21606371 |
| http://purl.uniprot.org/citations/21606371 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21606371 |
| http://purl.uniprot.org/uniprot/P01575#attribution-7DE0A7F13D697D70DFC559E1F42DB840 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21606371 |
| http://purl.uniprot.org/uniprot/P70671#attribution-7DE0A7F13D697D70DFC559E1F42DB840 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21606371 |
| http://purl.uniprot.org/uniprot/P33896#attribution-65694026C48A70CAE33FDA247DA5EFFB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21606371 |
| http://purl.uniprot.org/uniprot/Q62120#attribution-7DE0A7F13D697D70DFC559E1F42DB840 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21606371 |
| http://purl.uniprot.org/uniprot/P08505#attribution-7DE0A7F13D697D70DFC559E1F42DB840 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21606371 |
| http://purl.uniprot.org/uniprot/P43432#attribution-7DE0A7F13D697D70DFC559E1F42DB840 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21606371 |
| http://purl.uniprot.org/uniprot/O35716#attribution-65694026C48A70CAE33FDA247DA5EFFB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21606371 |
| http://purl.uniprot.org/uniprot/P42225#attribution-65694026C48A70CAE33FDA247DA5EFFB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21606371 |
| http://purl.uniprot.org/uniprot/P06804#attribution-7DE0A7F13D697D70DFC559E1F42DB840 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21606371 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGF4-mappedCitation-21606371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21606371 |
| http://purl.uniprot.org/uniprot/#_A0A087WSP5-mappedCitation-21606371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21606371 |