| http://purl.uniprot.org/citations/21606590 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21606590 | http://www.w3.org/2000/01/rdf-schema#comment | "Angiopoietin-1/Tek signaling is a critical regulator of blood vessel development, with conventional knockout of angiopoietin-1 or Tek in mice being embryonically lethal due to vascular defects. In addition, angiopoietin-1 is thought to be required for the stability of mature vessels. Using a Cre-Lox conditional gene targeting approach, we have studied the role of angiopoietin-1 in embryonic and adult vasculature. We report here that angiopoietin-1 is critical for regulating both the number and diameter of developing vessels but is not required for pericyte recruitment. Cardiac-specific knockout of angiopoietin-1 reproduced the phenotype of the conventional knockout, demonstrating that the early vascular abnormalities arise from flow-dependent defects. Strikingly, deletion in the entire embryo after day E13.5 produced no immediate vascular phenotype. However, when combined with injury or microvascular stress, angiopoietin-1 deficiency resulted in profound organ damage, accelerated angiogenesis, and fibrosis. These findings redefine our understanding of the biological roles of angiopoietin-1: it is dispensable in quiescent vessels but has a powerful ability to modulate the vascular response after injury."xsd:string |
| http://purl.uniprot.org/citations/21606590 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci46322"xsd:string |
| http://purl.uniprot.org/citations/21606590 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/21606590 | http://purl.uniprot.org/core/author | "Kerjaschki D."xsd:string |
| http://purl.uniprot.org/citations/21606590 | http://purl.uniprot.org/core/author | "Quaggin S.E."xsd:string |
| http://purl.uniprot.org/citations/21606590 | http://purl.uniprot.org/core/author | "Anderson G."xsd:string |
| http://purl.uniprot.org/citations/21606590 | http://purl.uniprot.org/core/author | "Gawlik A."xsd:string |
| http://purl.uniprot.org/citations/21606590 | http://purl.uniprot.org/core/author | "Henkelman M."xsd:string |
| http://purl.uniprot.org/citations/21606590 | http://purl.uniprot.org/core/author | "Jeansson M."xsd:string |
| http://purl.uniprot.org/citations/21606590 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21606590 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/21606590 | http://purl.uniprot.org/core/pages | "2278-2289"xsd:string |
| http://purl.uniprot.org/citations/21606590 | http://purl.uniprot.org/core/title | "Angiopoietin-1 is essential in mouse vasculature during development and in response to injury."xsd:string |
| http://purl.uniprot.org/citations/21606590 | http://purl.uniprot.org/core/volume | "121"xsd:string |
| http://purl.uniprot.org/citations/21606590 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21606590 |
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