| http://purl.uniprot.org/citations/2161148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2161148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2161148 | http://www.w3.org/2000/01/rdf-schema#comment | "Herpesvirus saimiri strains can be divided into at least three subgroups (A, B, C) based on sequence divergence at the left end of viral unique sequence DNA. Strains of subgroups A and C are highly oncogenic and readily transform simian T-lymphocytes in vitro to interleukin-2 independent growth, while subgroup B strains do not. A left terminal reading frame of a H. saimiri subgroup A strain was shown previously to correlate with the oncogenic phenotype and in vitro transforming potential; the deduced polypeptide was termed STP-A. Furthermore, this same region contains an open reading frame (ORF) for dihydrofolate reductase (DHFR) and genes for five virus-specific U RNAs (HSURs). We now show by sequence analysis of the corresponding region in a subgroup C strain that DHFR and HSUR genes are present in both virus subgroups; however, no sequence homologous to the STP-A reading frame was found in this subgroup C virus. At a position and orientation similar to STP-A, two ORFs were found for peptides sharing a putative transmembrane domain. One of them encodes a peptide with collagen-like repetitions. In addition to the lack of similarity to STP-A, these two reading frames also did not show any similarity to known oncogenes. The organization of sequences at the left junction of unique L- and repetitive H-DNA of H. saimiri suggests frequent recombinational events, possibly accelerating the uptake of foreign genes by the virus."xsd:string |
| http://purl.uniprot.org/citations/2161148 | http://purl.org/dc/terms/identifier | "doi:10.1016/0042-6822(90)90020-r"xsd:string |
| http://purl.uniprot.org/citations/2161148 | http://purl.org/dc/terms/identifier | "doi:10.1016/0042-6822(90)90020-r"xsd:string |
| http://purl.uniprot.org/citations/2161148 | http://purl.uniprot.org/core/author | "Biesinger B."xsd:string |
| http://purl.uniprot.org/citations/2161148 | http://purl.uniprot.org/core/author | "Biesinger B."xsd:string |
| http://purl.uniprot.org/citations/2161148 | http://purl.uniprot.org/core/author | "Fleckenstein B."xsd:string |
| http://purl.uniprot.org/citations/2161148 | http://purl.uniprot.org/core/author | "Fleckenstein B."xsd:string |
| http://purl.uniprot.org/citations/2161148 | http://purl.uniprot.org/core/author | "Desrosiers R.C."xsd:string |
| http://purl.uniprot.org/citations/2161148 | http://purl.uniprot.org/core/author | "Desrosiers R.C."xsd:string |
| http://purl.uniprot.org/citations/2161148 | http://purl.uniprot.org/core/author | "Trimble J.J."xsd:string |
| http://purl.uniprot.org/citations/2161148 | http://purl.uniprot.org/core/author | "Trimble J.J."xsd:string |
| http://purl.uniprot.org/citations/2161148 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2161148 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2161148 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/2161148 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/2161148 | http://purl.uniprot.org/core/pages | "505-514"xsd:string |
| http://purl.uniprot.org/citations/2161148 | http://purl.uniprot.org/core/pages | "505-514"xsd:string |
| http://purl.uniprot.org/citations/2161148 | http://purl.uniprot.org/core/title | "The divergence between two oncogenic Herpesvirus saimiri strains in a genomic region related to the transforming phenotype."xsd:string |
| http://purl.uniprot.org/citations/2161148 | http://purl.uniprot.org/core/title | "The divergence between two oncogenic Herpesvirus saimiri strains in a genomic region related to the transforming phenotype."xsd:string |
| http://purl.uniprot.org/citations/2161148 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/2161148 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/2161148 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2161148 |
| http://purl.uniprot.org/citations/2161148 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2161148 |