Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/21625173http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21625173http://www.w3.org/2000/01/rdf-schema#comment"

Background/aims

Interindividual variation in aspirin (ASA) metabolism is attributed to concomitant use of drugs or alcohol, urine pH, ethnicity, sex, and genetic variants in UDP-glucuronosyltransferases (UGT). Little is known about the effects of diet.

Methods

We evaluated cross-sectionally whether urinary excretion of ASA and its metabolites [salicylic acid (SA), salicyluric acid (SUA) phenolic glucuronide (SUAPG), salicylic acid acyl glucuronide (SAAG) and salicylic acid phenolic glucuronide (SAPG)] differed by UGT1A6 genotype and dietary factors shown to induce UGT. Following oral treatment with 650 mg ASA, urine was collected over 8 h in 264 men and 264 women (21-45 years old).

Results

There were statistically significant differences in metabolites excreted between sexes and ethnicities. Men excreted more SUA; women more ASA (p = 0.03), SA, SAAG and SAPG (p ≤ 0.001 for all). Compared to Caucasians, Asians excreted more ASA, SA and SAAG, and less SUA and SUAPG (p ≤ 0.03 for all); African-Americans excreted more SAAG and SAPG and less SUA (p ≤ 0.04). There was no effect of UGT1A6 genotypes. Increased ASA and decreased SUAPG excretion was observed with increased servings of vegetables (p = 0.008), specifically crucifers (p = 0.05).

Conclusion

Diet may influence the pharmacokinetics of ASA, but effects may be through modulation of glycine conjugation rather than glucuronidation."xsd:string
http://purl.uniprot.org/citations/21625173http://purl.org/dc/terms/identifier"doi:10.1159/000327782"xsd:string
http://purl.uniprot.org/citations/21625173http://purl.uniprot.org/core/author"Li L."xsd:string
http://purl.uniprot.org/citations/21625173http://purl.uniprot.org/core/author"Zheng Y."xsd:string
http://purl.uniprot.org/citations/21625173http://purl.uniprot.org/core/author"Levy L."xsd:string
http://purl.uniprot.org/citations/21625173http://purl.uniprot.org/core/author"Potter J.D."xsd:string
http://purl.uniprot.org/citations/21625173http://purl.uniprot.org/core/author"Bigler J."xsd:string
http://purl.uniprot.org/citations/21625173http://purl.uniprot.org/core/author"Saracino M.R."xsd:string
http://purl.uniprot.org/citations/21625173http://purl.uniprot.org/core/author"Thomas S.S."xsd:string
http://purl.uniprot.org/citations/21625173http://purl.uniprot.org/core/author"Lampe J.W."xsd:string
http://purl.uniprot.org/citations/21625173http://purl.uniprot.org/core/author"Makar K.W."xsd:string
http://purl.uniprot.org/citations/21625173http://purl.uniprot.org/core/author"Schwarz Y."xsd:string
http://purl.uniprot.org/citations/21625173http://purl.uniprot.org/core/author"Navarro S.L."xsd:string
http://purl.uniprot.org/citations/21625173http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21625173http://purl.uniprot.org/core/name"J Nutrigenet Nutrigenomics"xsd:string
http://purl.uniprot.org/citations/21625173http://purl.uniprot.org/core/pages"110-118"xsd:string
http://purl.uniprot.org/citations/21625173http://purl.uniprot.org/core/title"Determinants of aspirin metabolism in healthy men and women: effects of dietary inducers of UDP-glucuronosyltransferases."xsd:string
http://purl.uniprot.org/citations/21625173http://purl.uniprot.org/core/volume"4"xsd:string
http://purl.uniprot.org/citations/21625173http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21625173
http://purl.uniprot.org/citations/21625173http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/21625173
http://purl.uniprot.org/uniprot/#_P19224-mappedCitation-21625173http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21625173
http://purl.uniprot.org/uniprot/#_P22309-mappedCitation-21625173http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21625173
http://purl.uniprot.org/uniprot/#_P22310-mappedCitation-21625173http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21625173
http://purl.uniprot.org/uniprot/#_P35503-mappedCitation-21625173http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21625173
▶