| http://purl.uniprot.org/citations/21630250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21630250 | http://www.w3.org/2000/01/rdf-schema#comment | "TLR and complement activation ensures efficient clearance of infection. Previous studies documented synergism between TLRs and the receptor for the pro-inflammatory complement peptide C5a (C5aR/CD88), and regulation of TLR-induced pro-inflammatory responses by C5aR, suggesting crosstalk between TLRs and C5aR. However, it is unclear whether and how TLRs modulate C5a-induced pro-inflammatory responses. We demonstrate a marked positive modulatory effect of TLR activation on cell sensitivity to C5a in vitro and ex vivo and identify an underlying mechanistic target. Pre-exposure of PBMCs and whole blood to diverse TLR ligands or bacteria enhanced C5a-induced pro-inflammatory responses. This effect was not observed in TLR4 signalling-deficient mice. TLR-induced hypersensitivity to C5a did not result from C5aR upregulation or modulation of C5a-induced Ca(2+) mobilization. Rather, TLRs targeted another C5a receptor, C5L2 (acting as a negative modulator of C5aR), by reducing C5L2 activity. TLR-induced hypersensitivity to C5a was mimicked by blocking C5L2 and was not observed in C5L2KO mice. Furthermore, TLR activation inhibited C5L2 expression upon C5a stimulation. These findings identify a novel pathway of crosstalk within the innate immune system that amplifies innate host defense at the TLR-complement interface. Unravelling the mutually regulated activities of TLRs and complement may reveal new therapeutic avenues to control inflammation."xsd:string |
| http://purl.uniprot.org/citations/21630250 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201041350"xsd:string |
| http://purl.uniprot.org/citations/21630250 | http://purl.uniprot.org/core/author | "Davies J."xsd:string |
| http://purl.uniprot.org/citations/21630250 | http://purl.uniprot.org/core/author | "Shah S."xsd:string |
| http://purl.uniprot.org/citations/21630250 | http://purl.uniprot.org/core/author | "Hall J."xsd:string |
| http://purl.uniprot.org/citations/21630250 | http://purl.uniprot.org/core/author | "Morgan B.P."xsd:string |
| http://purl.uniprot.org/citations/21630250 | http://purl.uniprot.org/core/author | "Holst B."xsd:string |
| http://purl.uniprot.org/citations/21630250 | http://purl.uniprot.org/core/author | "Kohl J."xsd:string |
| http://purl.uniprot.org/citations/21630250 | http://purl.uniprot.org/core/author | "Coles B."xsd:string |
| http://purl.uniprot.org/citations/21630250 | http://purl.uniprot.org/core/author | "Topley N."xsd:string |
| http://purl.uniprot.org/citations/21630250 | http://purl.uniprot.org/core/author | "Laumonnier Y."xsd:string |
| http://purl.uniprot.org/citations/21630250 | http://purl.uniprot.org/core/author | "Colmont C."xsd:string |
| http://purl.uniprot.org/citations/21630250 | http://purl.uniprot.org/core/author | "Labeta M.O."xsd:string |
| http://purl.uniprot.org/citations/21630250 | http://purl.uniprot.org/core/author | "Raby A.C."xsd:string |
| http://purl.uniprot.org/citations/21630250 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21630250 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21630250 | http://purl.uniprot.org/core/pages | "2741-2752"xsd:string |
| http://purl.uniprot.org/citations/21630250 | http://purl.uniprot.org/core/title | "TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor, C5L2."xsd:string |
| http://purl.uniprot.org/citations/21630250 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/21630250 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21630250 |
| http://purl.uniprot.org/citations/21630250 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21630250 |
| http://purl.uniprot.org/uniprot/#_E9QQ21-mappedCitation-21630250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21630250 |
| http://purl.uniprot.org/uniprot/#_E9PVQ2-mappedCitation-21630250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21630250 |
| http://purl.uniprot.org/uniprot/#_Q8BW93-mappedCitation-21630250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21630250 |