| http://purl.uniprot.org/citations/21632562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21632562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21632562 | http://www.w3.org/2000/01/rdf-schema#comment | "Human respiratory syncytial virus (RSV), a leading cause of respiratory tract infections in infants, inhibits type I interferon (IFN)-dependent signalling, as well as IFN synthesis. RSV non-structural protein NS1 plays a significant role in this inhibition; however, the mechanism(s) responsible is not fully known. The transcription factor interferon regulatory factor (IRF)-3 is essential for viral-induced IFN-β synthesis. In this study, we found that NS1 protein inhibits IRF-3-dependent gene transcription in constitutively active IRF-3 overexpressing cells, demonstrating that NS1 directly targets IRF-3. Our data also demonstrate that NS1 associates with IRF-3 and its transcriptional coactivator CBP, leading to disrupted association of IRF-3 to CBP and subsequent reduced binding of IRF-3 to the IFN-β promoter without blocking viral-induced IRF-3 phosphorylation, nuclear translocation and dimerization, thereby identifying a novel molecular mechanism by which RSV inhibits IFN-β synthesis."xsd:string |
| http://purl.uniprot.org/citations/21632562 | http://purl.org/dc/terms/identifier | "doi:10.1099/vir.0.032987-0"xsd:string |
| http://purl.uniprot.org/citations/21632562 | http://purl.org/dc/terms/identifier | "doi:10.1099/vir.0.032987-0"xsd:string |
| http://purl.uniprot.org/citations/21632562 | http://purl.uniprot.org/core/author | "Liu T."xsd:string |
| http://purl.uniprot.org/citations/21632562 | http://purl.uniprot.org/core/author | "Liu T."xsd:string |
| http://purl.uniprot.org/citations/21632562 | http://purl.uniprot.org/core/author | "Li K."xsd:string |
| http://purl.uniprot.org/citations/21632562 | http://purl.uniprot.org/core/author | "Li K."xsd:string |
| http://purl.uniprot.org/citations/21632562 | http://purl.uniprot.org/core/author | "Ren J."xsd:string |
| http://purl.uniprot.org/citations/21632562 | http://purl.uniprot.org/core/author | "Ren J."xsd:string |
| http://purl.uniprot.org/citations/21632562 | http://purl.uniprot.org/core/author | "Bao X."xsd:string |
| http://purl.uniprot.org/citations/21632562 | http://purl.uniprot.org/core/author | "Bao X."xsd:string |
| http://purl.uniprot.org/citations/21632562 | http://purl.uniprot.org/core/author | "Casola A."xsd:string |
| http://purl.uniprot.org/citations/21632562 | http://purl.uniprot.org/core/author | "Casola A."xsd:string |
| http://purl.uniprot.org/citations/21632562 | http://purl.uniprot.org/core/author | "Garofalo R.P."xsd:string |
| http://purl.uniprot.org/citations/21632562 | http://purl.uniprot.org/core/author | "Garofalo R.P."xsd:string |
| http://purl.uniprot.org/citations/21632562 | http://purl.uniprot.org/core/author | "Pang L."xsd:string |
| http://purl.uniprot.org/citations/21632562 | http://purl.uniprot.org/core/author | "Pang L."xsd:string |
| http://purl.uniprot.org/citations/21632562 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21632562 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21632562 | http://purl.uniprot.org/core/name | "J. Gen. Virol."xsd:string |
| http://purl.uniprot.org/citations/21632562 | http://purl.uniprot.org/core/name | "J. Gen. Virol."xsd:string |
| http://purl.uniprot.org/citations/21632562 | http://purl.uniprot.org/core/pages | "2153-2159"xsd:string |
| http://purl.uniprot.org/citations/21632562 | http://purl.uniprot.org/core/pages | "2153-2159"xsd:string |