http://purl.uniprot.org/citations/21633298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/21633298 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo evaluate the expression and prognostic significance of survivin, CD117, and C-erbB-2 in neuroendocrine carcinoma of the uterine cervix.Materials and methodsImmunohistochemical stains of survivin, CD117, and C-erbB-2 were evaluated in 100 cases of cervical neuroendocrine carcinoma. The findings were correlated with clinicopathologic variables and disease-free survival.ResultsExpressions of survivin, CD117, and C-erbB-2 were detected in 27.0%, 12.0%, and 2.0% of the cases, respectively. Survivin-positive patients had a significantly younger mean age than the survivin-negative group (P=0.033). In early-stage cases, tumor recurrence was significantly associated with lymph node metastasis (P=0.005), depth of invasion (P=0.028), and the presence of lymphovascular space invasion (P=0.031) but not with the expression of survivin or CD117. Subgroup analysis in early-stage cases without lymph node metastasis (n=32) showed that only survivin expression had a significant association with decreased disease-free survival (P=0.041).ConclusionsSurvivin expression may be a prognostic indicator for survival in early-stage neuroendocrine carcinoma of the uterine cervix without lymph node metastasis. Adjuvant survivin-targeted therapy may have potential benefit in patients with this tumor."xsd:string |
http://purl.uniprot.org/citations/21633298 | http://purl.org/dc/terms/identifier | "doi:10.1097/igc.0b013e31821a2567"xsd:string |
http://purl.uniprot.org/citations/21633298 | http://purl.uniprot.org/core/author | "Cheewakriangkrai C."xsd:string |
http://purl.uniprot.org/citations/21633298 | http://purl.uniprot.org/core/author | "Khunamornpong S."xsd:string |
http://purl.uniprot.org/citations/21633298 | http://purl.uniprot.org/core/author | "Settakorn J."xsd:string |
http://purl.uniprot.org/citations/21633298 | http://purl.uniprot.org/core/author | "Siriaunkgul S."xsd:string |
http://purl.uniprot.org/citations/21633298 | http://purl.uniprot.org/core/author | "Srisomboon J."xsd:string |
http://purl.uniprot.org/citations/21633298 | http://purl.uniprot.org/core/author | "Sukpan K."xsd:string |
http://purl.uniprot.org/citations/21633298 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
http://purl.uniprot.org/citations/21633298 | http://purl.uniprot.org/core/name | "Int J Gynecol Cancer"xsd:string |
http://purl.uniprot.org/citations/21633298 | http://purl.uniprot.org/core/pages | "911-917"xsd:string |
http://purl.uniprot.org/citations/21633298 | http://purl.uniprot.org/core/title | "Expression of survivin, CD117, and C-erbB-2 in neuroendocrine carcinoma of the uterine cervix."xsd:string |
http://purl.uniprot.org/citations/21633298 | http://purl.uniprot.org/core/volume | "21"xsd:string |
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