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http://purl.uniprot.org/citations/21633298http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21633298http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To evaluate the expression and prognostic significance of survivin, CD117, and C-erbB-2 in neuroendocrine carcinoma of the uterine cervix.

Materials and methods

Immunohistochemical stains of survivin, CD117, and C-erbB-2 were evaluated in 100 cases of cervical neuroendocrine carcinoma. The findings were correlated with clinicopathologic variables and disease-free survival.

Results

Expressions of survivin, CD117, and C-erbB-2 were detected in 27.0%, 12.0%, and 2.0% of the cases, respectively. Survivin-positive patients had a significantly younger mean age than the survivin-negative group (P=0.033). In early-stage cases, tumor recurrence was significantly associated with lymph node metastasis (P=0.005), depth of invasion (P=0.028), and the presence of lymphovascular space invasion (P=0.031) but not with the expression of survivin or CD117. Subgroup analysis in early-stage cases without lymph node metastasis (n=32) showed that only survivin expression had a significant association with decreased disease-free survival (P=0.041).

Conclusions

Survivin expression may be a prognostic indicator for survival in early-stage neuroendocrine carcinoma of the uterine cervix without lymph node metastasis. Adjuvant survivin-targeted therapy may have potential benefit in patients with this tumor."xsd:string
http://purl.uniprot.org/citations/21633298http://purl.org/dc/terms/identifier"doi:10.1097/igc.0b013e31821a2567"xsd:string
http://purl.uniprot.org/citations/21633298http://purl.uniprot.org/core/author"Cheewakriangkrai C."xsd:string
http://purl.uniprot.org/citations/21633298http://purl.uniprot.org/core/author"Khunamornpong S."xsd:string
http://purl.uniprot.org/citations/21633298http://purl.uniprot.org/core/author"Settakorn J."xsd:string
http://purl.uniprot.org/citations/21633298http://purl.uniprot.org/core/author"Siriaunkgul S."xsd:string
http://purl.uniprot.org/citations/21633298http://purl.uniprot.org/core/author"Srisomboon J."xsd:string
http://purl.uniprot.org/citations/21633298http://purl.uniprot.org/core/author"Sukpan K."xsd:string
http://purl.uniprot.org/citations/21633298http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21633298http://purl.uniprot.org/core/name"Int J Gynecol Cancer"xsd:string
http://purl.uniprot.org/citations/21633298http://purl.uniprot.org/core/pages"911-917"xsd:string
http://purl.uniprot.org/citations/21633298http://purl.uniprot.org/core/title"Expression of survivin, CD117, and C-erbB-2 in neuroendocrine carcinoma of the uterine cervix."xsd:string
http://purl.uniprot.org/citations/21633298http://purl.uniprot.org/core/volume"21"xsd:string
http://purl.uniprot.org/citations/21633298http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21633298
http://purl.uniprot.org/citations/21633298http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/21633298
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