| http://purl.uniprot.org/citations/21640790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21640790 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNA-146a (miRNA-146a) is an inducible, 22 nucleotide, small RNA over-expressed in Alzheimer's disease (AD) brain. Up-regulated miRNA-146a targets several inflammation-related and membrane-associated messenger RNAs (mRNAs), including those encoding complement factor-H (CFH) and the interleukin-1 receptor associated kinase-1 (IRAK-1), resulting in significant decreases in their expression (p<0.05, ANOVA). In this study we assayed miRNA-146a, CFH, IRAK-1 and tetraspanin-12 (TSPAN12), abundances in primary human neuronal-glial (HNG) co-cultures, in human astroglial (HAG) and microglial (HMG) cells stressed with Aβ42 peptide and tumor necrosis factor alpha (TNFα). The results indicate a consistent inverse relationship between miRNA-146a and CFH, IRAK-1 and TSPAN12 expression levels, and indicate that HNG, HAG and HMG cell types each respond differently to Aβ42-peptide+TNFα-triggered stress. While the strongest miRNA-146a-IRAK-1 response was found in HAG cells, the largest miRNA-146a-TSPAN12 response was found in HNG cells, and the most significant miRNA-146a-CFH changes were found in HMG cells, the 'resident scavenging macrophages' of the brain."xsd:string |
| http://purl.uniprot.org/citations/21640790 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neulet.2011.05.044"xsd:string |
| http://purl.uniprot.org/citations/21640790 | http://purl.uniprot.org/core/author | "Bhattacharjee S."xsd:string |
| http://purl.uniprot.org/citations/21640790 | http://purl.uniprot.org/core/author | "Li Y.Y."xsd:string |
| http://purl.uniprot.org/citations/21640790 | http://purl.uniprot.org/core/author | "Cui J.G."xsd:string |
| http://purl.uniprot.org/citations/21640790 | http://purl.uniprot.org/core/author | "Lukiw W.J."xsd:string |
| http://purl.uniprot.org/citations/21640790 | http://purl.uniprot.org/core/author | "Pogue A.I."xsd:string |
| http://purl.uniprot.org/citations/21640790 | http://purl.uniprot.org/core/author | "Dua P."xsd:string |
| http://purl.uniprot.org/citations/21640790 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21640790 | http://purl.uniprot.org/core/name | "Neurosci Lett"xsd:string |
| http://purl.uniprot.org/citations/21640790 | http://purl.uniprot.org/core/pages | "109-113"xsd:string |
| http://purl.uniprot.org/citations/21640790 | http://purl.uniprot.org/core/title | "Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells."xsd:string |
| http://purl.uniprot.org/citations/21640790 | http://purl.uniprot.org/core/volume | "499"xsd:string |
| http://purl.uniprot.org/citations/21640790 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21640790 |
| http://purl.uniprot.org/citations/21640790 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21640790 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MRG2-mappedCitation-21640790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21640790 |
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