| http://purl.uniprot.org/citations/21640852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21640852 | http://www.w3.org/2000/01/rdf-schema#comment | "The anti-cancer activity of sulforaphane (SFN) has recently been investigated in several cancer cell lines, including human hepatic cancers. However, the mechanism of SFN-induced cell death in human hepatic cancer cells is still not well understood. The aim of the present work is to explore the possible mechanisms of SFN-induced apoptosis in hepatocellular carcinoma cells using proteomic analysis. A two-dimensional electrophoresis (2-DE)-based-proteomic analysis was employed for identification of possible target-related proteins of SFN-induced apoptosis. Among eleven proteins identified as regulated, we focused on the down-regulation of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase4 (PFKFB4) protein, which has been known as a key modulator of glycolysis. We also showed that SFN down-regulated the expression of the transcriptional factor, hypoxia inducible factor-1α (HIF-1α), which strongly regulates PFKFB4 expression. In order to obtain a broad understanding of the correlation of HIF-1α and SFN, we observed the inhibition of the activity of mitogen-activated protein kinases, regulators of HIF-1α activity. Our findings suggest that SFN is a potent inducer of apoptosis in hepatocellular carcinoma cells via PFKFB4-inhibition pathways. HIF-1 pathway inhibition may be mediated by the inhibition of mitogen-activated protein kinases."xsd:string |
| http://purl.uniprot.org/citations/21640852 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbapap.2011.05.015"xsd:string |
| http://purl.uniprot.org/citations/21640852 | http://purl.uniprot.org/core/author | "Jang S.Y."xsd:string |
| http://purl.uniprot.org/citations/21640852 | http://purl.uniprot.org/core/author | "Jang Y.H."xsd:string |
| http://purl.uniprot.org/citations/21640852 | http://purl.uniprot.org/core/author | "Nam M.J."xsd:string |
| http://purl.uniprot.org/citations/21640852 | http://purl.uniprot.org/core/author | "Jeon Y.K."xsd:string |
| http://purl.uniprot.org/citations/21640852 | http://purl.uniprot.org/core/author | "Yoo D.R."xsd:string |
| http://purl.uniprot.org/citations/21640852 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21640852 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/21640852 | http://purl.uniprot.org/core/pages | "1340-1348"xsd:string |
| http://purl.uniprot.org/citations/21640852 | http://purl.uniprot.org/core/title | "Sulforaphane induces apoptosis in human hepatic cancer cells through inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase4, mediated by hypoxia inducible factor-1-dependent pathway."xsd:string |
| http://purl.uniprot.org/citations/21640852 | http://purl.uniprot.org/core/volume | "1814"xsd:string |
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