| http://purl.uniprot.org/citations/21642972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21642972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21642972 | http://www.w3.org/2000/01/rdf-schema#comment | "UNC119 is widely expressed among vertebrates and other phyla. We found that UNC119 recognized the acylated N terminus of the rod photoreceptor transducin α (Tα) subunit and Caenorhabditis elegans G proteins ODR-3 and GPA-13. The crystal structure of human UNC119 at 1.95-Å resolution revealed an immunoglobulin-like β-sandwich fold. Pulldowns and isothermal titration calorimetry revealed a tight interaction between UNC119 and acylated Gα peptides. The structure of co-crystals of UNC119 with an acylated Tα N-terminal peptide at 2.0 Å revealed that the lipid chain is buried deeply into UNC119's hydrophobic cavity. UNC119 bound Tα-GTP, inhibiting its GTPase activity, thereby providing a stable UNC119-Tα-GTP complex capable of diffusing from the inner segment back to the outer segment after light-induced translocation. UNC119 deletion in both mouse and C. elegans led to G protein mislocalization. Thus, UNC119 is a Gα subunit cofactor essential for G protein trafficking in sensory cilia."xsd:string |
| http://purl.uniprot.org/citations/21642972 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.2835"xsd:string |
| http://purl.uniprot.org/citations/21642972 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.2835"xsd:string |
| http://purl.uniprot.org/citations/21642972 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/21642972 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/21642972 | http://purl.uniprot.org/core/author | "Hill C.P."xsd:string |
| http://purl.uniprot.org/citations/21642972 | http://purl.uniprot.org/core/author | "Hill C.P."xsd:string |
| http://purl.uniprot.org/citations/21642972 | http://purl.uniprot.org/core/author | "Montelione G.T."xsd:string |
| http://purl.uniprot.org/citations/21642972 | http://purl.uniprot.org/core/author | "Montelione G.T."xsd:string |
| http://purl.uniprot.org/citations/21642972 | http://purl.uniprot.org/core/author | "Seetharaman J."xsd:string |
| http://purl.uniprot.org/citations/21642972 | http://purl.uniprot.org/core/author | "Seetharaman J."xsd:string |
| http://purl.uniprot.org/citations/21642972 | http://purl.uniprot.org/core/author | "Tong L."xsd:string |
| http://purl.uniprot.org/citations/21642972 | http://purl.uniprot.org/core/author | "Tong L."xsd:string |
| http://purl.uniprot.org/citations/21642972 | http://purl.uniprot.org/core/author | "Xiao R."xsd:string |
| http://purl.uniprot.org/citations/21642972 | http://purl.uniprot.org/core/author | "Xiao R."xsd:string |
| http://purl.uniprot.org/citations/21642972 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/21642972 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/21642972 | http://purl.uniprot.org/core/author | "Whitby F.G."xsd:string |
| http://purl.uniprot.org/citations/21642972 | http://purl.uniprot.org/core/author | "Whitby F.G."xsd:string |
| http://purl.uniprot.org/citations/21642972 | http://purl.uniprot.org/core/author | "Vorobiev S."xsd:string |
| http://purl.uniprot.org/citations/21642972 | http://purl.uniprot.org/core/author | "Vorobiev S."xsd:string |
| http://purl.uniprot.org/citations/21642972 | http://purl.uniprot.org/core/author | "Baehr W."xsd:string |
| http://purl.uniprot.org/citations/21642972 | http://purl.uniprot.org/core/author | "Baehr W."xsd:string |