| http://purl.uniprot.org/citations/21642987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21642987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21642987 | http://www.w3.org/2000/01/rdf-schema#comment | "Antiviral innate immunity relies on the recognition of microbial structures. One such structure is viral RNA that carries a triphosphate group on its 5' terminus (PPP-RNA). By an affinity proteomics approach with PPP-RNA as the 'bait', we found that the antiviral protein IFIT1 (interferon-induced protein with tetratricopeptide repeats 1) mediated binding of a larger protein complex containing other IFIT family members. IFIT1 bound PPP-RNA with nanomolar affinity and required the arginine at position 187 in a highly charged carboxy-terminal groove of the protein. In the absence of IFIT1, the growth and pathogenicity of viruses containing PPP-RNA was much greater. In contrast, IFIT proteins were dispensable for the clearance of pathogens that did not generate PPP-RNA. On the basis of this specificity and the great abundance of IFIT proteins after infection, we propose that the IFIT complex antagonizes viruses by sequestering specific viral nucleic acids."xsd:string |
| http://purl.uniprot.org/citations/21642987 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.2048"xsd:string |
| http://purl.uniprot.org/citations/21642987 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.2048"xsd:string |
| http://purl.uniprot.org/citations/21642987 | http://purl.uniprot.org/core/author | "Bennett K.L."xsd:string |
| http://purl.uniprot.org/citations/21642987 | http://purl.uniprot.org/core/author | "Bennett K.L."xsd:string |
| http://purl.uniprot.org/citations/21642987 | http://purl.uniprot.org/core/author | "Buerckstuemmer T."xsd:string |
| http://purl.uniprot.org/citations/21642987 | http://purl.uniprot.org/core/author | "Buerckstuemmer T."xsd:string |
| http://purl.uniprot.org/citations/21642987 | http://purl.uniprot.org/core/author | "Burkard T.R."xsd:string |
| http://purl.uniprot.org/citations/21642987 | http://purl.uniprot.org/core/author | "Burkard T.R."xsd:string |
| http://purl.uniprot.org/citations/21642987 | http://purl.uniprot.org/core/author | "Colinge J."xsd:string |
| http://purl.uniprot.org/citations/21642987 | http://purl.uniprot.org/core/author | "Colinge J."xsd:string |
| http://purl.uniprot.org/citations/21642987 | http://purl.uniprot.org/core/author | "Mueller M."xsd:string |
| http://purl.uniprot.org/citations/21642987 | http://purl.uniprot.org/core/author | "Mueller M."xsd:string |
| http://purl.uniprot.org/citations/21642987 | http://purl.uniprot.org/core/author | "Superti-Furga G."xsd:string |
| http://purl.uniprot.org/citations/21642987 | http://purl.uniprot.org/core/author | "Superti-Furga G."xsd:string |
| http://purl.uniprot.org/citations/21642987 | http://purl.uniprot.org/core/author | "Ruelicke T."xsd:string |
| http://purl.uniprot.org/citations/21642987 | http://purl.uniprot.org/core/author | "Ruelicke T."xsd:string |
| http://purl.uniprot.org/citations/21642987 | http://purl.uniprot.org/core/author | "Krieger S."xsd:string |
| http://purl.uniprot.org/citations/21642987 | http://purl.uniprot.org/core/author | "Krieger S."xsd:string |
| http://purl.uniprot.org/citations/21642987 | http://purl.uniprot.org/core/author | "Weber F."xsd:string |
| http://purl.uniprot.org/citations/21642987 | http://purl.uniprot.org/core/author | "Weber F."xsd:string |
| http://purl.uniprot.org/citations/21642987 | http://purl.uniprot.org/core/author | "Pichlmair A."xsd:string |
| http://purl.uniprot.org/citations/21642987 | http://purl.uniprot.org/core/author | "Pichlmair A."xsd:string |