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http://purl.uniprot.org/citations/21644221http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21644221http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To study the association between the single nucleotide polymorphisms (SNPs) of the 5'-untranslated region (5'-UTR) of phospholipid hydroperoxide glutathione peroxidase (GPx4 or PHGPx) gene and oligo- or asthenozoospermic male infertility.

Methods

The 5'-UTR region of the GPx4 gene was amplified from infertile men and controls using the polymerase chain reaction and was analyzed for polymorphisms by direct sequencing.

Results

A total of 9 SNPs were present in the cohort, however there were no significant differences in these 9 SNPs between the case and control groups. According to the results of linkage disequilibrium analysis and haplotype construction, one haplotype (rs757229-rs757230-rs4588110-rs3746165-rs3746166: C-G-G-T-A) was present only in the control men, and significant difference was detected(P< 0.01).

Conclusion

The SNPs of 5'-UTR region of the GPx4 gene might not be associated with oligo- or asthenozoospermic male infertility. However, the haplotype (rs757229-rs757230-rs4588110-rs3746165-rs3746166: C-G-G-T-A) might be a protective haplotype."xsd:string
http://purl.uniprot.org/citations/21644221http://purl.org/dc/terms/identifier"doi:10.3760/cma.j.issn.1003-9406.2011.03.007"xsd:string
http://purl.uniprot.org/citations/21644221http://purl.uniprot.org/core/author"Chu J.Y."xsd:string
http://purl.uniprot.org/citations/21644221http://purl.uniprot.org/core/author"Sun H."xsd:string
http://purl.uniprot.org/citations/21644221http://purl.uniprot.org/core/author"Yu L."xsd:string
http://purl.uniprot.org/citations/21644221http://purl.uniprot.org/core/author"Shi L."xsd:string
http://purl.uniprot.org/citations/21644221http://purl.uniprot.org/core/author"Liu S.Y."xsd:string
http://purl.uniprot.org/citations/21644221http://purl.uniprot.org/core/author"Yang Z.Q."xsd:string
http://purl.uniprot.org/citations/21644221http://purl.uniprot.org/core/author"Zhang C.J."xsd:string
http://purl.uniprot.org/citations/21644221http://purl.uniprot.org/core/author"Yao Y.F."xsd:string
http://purl.uniprot.org/citations/21644221http://purl.uniprot.org/core/author"Huang X.Q."xsd:string
http://purl.uniprot.org/citations/21644221http://purl.uniprot.org/core/author"Shi L.'"xsd:string
http://purl.uniprot.org/citations/21644221http://purl.uniprot.org/core/author"Ke J.K."xsd:string
http://purl.uniprot.org/citations/21644221http://purl.uniprot.org/core/author"Si X.M."xsd:string
http://purl.uniprot.org/citations/21644221http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21644221http://purl.uniprot.org/core/name"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/21644221http://purl.uniprot.org/core/pages"270-274"xsd:string
http://purl.uniprot.org/citations/21644221http://purl.uniprot.org/core/title"[Association between single nucleotide polymorphisms of 5'-untranslated region of GPx4 gene and male infertility]."xsd:string
http://purl.uniprot.org/citations/21644221http://purl.uniprot.org/core/volume"28"xsd:string
http://purl.uniprot.org/citations/21644221http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21644221
http://purl.uniprot.org/citations/21644221http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/21644221
http://purl.uniprot.org/uniprot/#_A0A384MTT0-mappedCitation-21644221http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21644221
http://purl.uniprot.org/uniprot/#_Q6PJX4-mappedCitation-21644221http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21644221
http://purl.uniprot.org/uniprot/#_P36969-mappedCitation-21644221http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21644221
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