| http://purl.uniprot.org/citations/21652681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21652681 | http://www.w3.org/2000/01/rdf-schema#comment | "Deficiencies in the IL-7 signaling pathway result in severe disruptions of lymphoid development in adult mice. To understand more about how IL-7 deficiency impacts early lymphoid development, we have investigated lineage restriction events within the common lymphoid progenitor (CLP) compartment in IL-7 knockout mice. This revealed that although IL-7 deficiency had a minor impact on the development of LY6D(-) multipotent CLPs, the formation of the lineage restricted LY6D(+) CLP population was dramatically reduced. This was reflected in a low-level transcription of B-lineage genes as well as in a loss of functional B-cell commitment. The few Ly6D(+) CLPs developed in the absence of IL-7 displayed increased lineage plasticity and low expression of Ebf-1. Absence of Ebf-1 could be linked to increased plasticity because even though Ly6D(+) cells develop in Ebf-1-deficient mice, these cells retain both natural killer and dendritic cell potential. This reveals that IL-7 is essential for normal development of Ly6D(+) CLPs and that Ebf-1 is crucial for lineage restriction in early lymphoid progenitors."xsd:string |
| http://purl.uniprot.org/citations/21652681 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2011-01-332189"xsd:string |
| http://purl.uniprot.org/citations/21652681 | http://purl.uniprot.org/core/author | "Qian H."xsd:string |
| http://purl.uniprot.org/citations/21652681 | http://purl.uniprot.org/core/author | "Jonsson J.I."xsd:string |
| http://purl.uniprot.org/citations/21652681 | http://purl.uniprot.org/core/author | "Sigvardsson M."xsd:string |
| http://purl.uniprot.org/citations/21652681 | http://purl.uniprot.org/core/author | "Zandi S."xsd:string |
| http://purl.uniprot.org/citations/21652681 | http://purl.uniprot.org/core/author | "Tsapogas P."xsd:string |
| http://purl.uniprot.org/citations/21652681 | http://purl.uniprot.org/core/author | "Mansson R."xsd:string |
| http://purl.uniprot.org/citations/21652681 | http://purl.uniprot.org/core/author | "Zetterblad J."xsd:string |
| http://purl.uniprot.org/citations/21652681 | http://purl.uniprot.org/core/author | "Welinder E."xsd:string |
| http://purl.uniprot.org/citations/21652681 | http://purl.uniprot.org/core/author | "Ahsberg J."xsd:string |
| http://purl.uniprot.org/citations/21652681 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21652681 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/21652681 | http://purl.uniprot.org/core/pages | "1283-1290"xsd:string |
| http://purl.uniprot.org/citations/21652681 | http://purl.uniprot.org/core/title | "IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors."xsd:string |
| http://purl.uniprot.org/citations/21652681 | http://purl.uniprot.org/core/volume | "118"xsd:string |
| http://purl.uniprot.org/citations/21652681 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21652681 |
| http://purl.uniprot.org/citations/21652681 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21652681 |
| http://purl.uniprot.org/uniprot/#_Q07802-mappedCitation-21652681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21652681 |
| http://purl.uniprot.org/uniprot/#_P10168-mappedCitation-21652681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21652681 |
| http://purl.uniprot.org/uniprot/#_Q3UT18-mappedCitation-21652681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21652681 |
| http://purl.uniprot.org/uniprot/#_Q8BSM3-mappedCitation-21652681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21652681 |
| http://purl.uniprot.org/uniprot/#_Q5SWK4-mappedCitation-21652681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21652681 |
| http://purl.uniprot.org/uniprot/#_Q5SWK5-mappedCitation-21652681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21652681 |