| http://purl.uniprot.org/citations/2165484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2165484 | http://www.w3.org/2000/01/rdf-schema#comment | "Keratinocyte growth factor (KGF) is a member of the fibroblast growth factor (FGF) family. KGF exhibits potent mitogenic activity for a variety of epithelial cell types but is distinct from other known FGFs in that it is not mitogenic for fibroblasts or endothelial cells. We report saturable specific binding of 125I-KGF to surface receptors on intact Balb/MK mouse epidermal keratinocytes. 125I-KGF binding was completed efficiently by acidic FGF (aFGF) but with 20-fold lower efficiency by basic FGF (bFGF). The pattern of 125I-acidic FGF binding and competition on Balb/MK keratinocytes and NIH/3T3 fibroblasts suggests that these cell types possess related but distinct FGF receptors. Scatchard analysis of 125I-KGF binding suggested major and minor high affinity receptor components (KD = 400 and 25 pM, respectively) as well as a third high capacity/low affinity heparin-like component. Covalent affinity cross-linking of 125I-KGF to its receptor on Balb/MK cells revealed two species of 115 and 140 kDa. KGF also stimulated the rapid tyrosine phosphorylation of a 90-kDa protein in Balb/MK cells but not in NIH/3T3 fibroblasts. Together these results indicate that Balb/MK keratinocytes possess high affinity KGF receptors to which the FGFs may also bind. However, these receptors are distinct from the receptor(s) for aFGF and bFGF on NIH/3T3 fibroblasts, which fail to interact with KGF."xsd:string |
| http://purl.uniprot.org/citations/2165484 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(19)38222-5"xsd:string |
| http://purl.uniprot.org/citations/2165484 | http://purl.uniprot.org/core/author | "Aaronson S.A."xsd:string |
| http://purl.uniprot.org/citations/2165484 | http://purl.uniprot.org/core/author | "Finch P.W."xsd:string |
| http://purl.uniprot.org/citations/2165484 | http://purl.uniprot.org/core/author | "Rubin J.S."xsd:string |
| http://purl.uniprot.org/citations/2165484 | http://purl.uniprot.org/core/author | "Ron D."xsd:string |
| http://purl.uniprot.org/citations/2165484 | http://purl.uniprot.org/core/author | "Florio C."xsd:string |
| http://purl.uniprot.org/citations/2165484 | http://purl.uniprot.org/core/author | "Bottaro D.P."xsd:string |
| http://purl.uniprot.org/citations/2165484 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2165484 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/2165484 | http://purl.uniprot.org/core/pages | "12767-12770"xsd:string |
| http://purl.uniprot.org/citations/2165484 | http://purl.uniprot.org/core/title | "Characterization of the receptor for keratinocyte growth factor. Evidence for multiple fibroblast growth factor receptors."xsd:string |
| http://purl.uniprot.org/citations/2165484 | http://purl.uniprot.org/core/volume | "265"xsd:string |
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