| http://purl.uniprot.org/citations/21654840 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21654840 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21654840 | http://www.w3.org/2000/01/rdf-schema#comment | "Caspase-14 is a protease that is mainly expressed in suprabasal epidermal layers and activated during keratinocyte cornification. Caspase-14-deficient mice display reduced epidermal barrier function and increased sensitivity to UVB radiation. In these mice, profilaggrin, a protein with a pivotal role in skin barrier function, is processed correctly to its functional filaggrin (FLG) repeat unit, but proteolytic FLG fragments accumulate in the epidermis. In wild-type stratum corneum, FLG is degraded into free amino acids, some of which contribute to generation of the natural moisturizing factors (NMFs) that maintain epidermal hydration. We found that caspase-14 cleaves the FLG repeat unit and identified two caspase-14 cleavage sites. These results indicate that accumulation of FLG fragments in caspase-14(-/-) mice is due to a defect in the terminal FLG degradation pathway. Consequently, we show that the defective FLG degradation in caspase-14-deficient skin results in substantial reduction in the amount of NMFs, such as urocanic acid and pyrrolidone carboxylic acid. Taken together, we identified caspase-14 as a crucial protease in FLG catabolism."xsd:string |
| http://purl.uniprot.org/citations/21654840 | http://purl.org/dc/terms/identifier | "doi:10.1038/jid.2011.153"xsd:string |
| http://purl.uniprot.org/citations/21654840 | http://purl.org/dc/terms/identifier | "doi:10.1038/jid.2011.153"xsd:string |
| http://purl.uniprot.org/citations/21654840 | http://purl.uniprot.org/core/author | "Gevaert K."xsd:string |
| http://purl.uniprot.org/citations/21654840 | http://purl.uniprot.org/core/author | "Gevaert K."xsd:string |
| http://purl.uniprot.org/citations/21654840 | http://purl.uniprot.org/core/author | "Van Damme P."xsd:string |
| http://purl.uniprot.org/citations/21654840 | http://purl.uniprot.org/core/author | "Van Damme P."xsd:string |
| http://purl.uniprot.org/citations/21654840 | http://purl.uniprot.org/core/author | "Caspers P."xsd:string |
| http://purl.uniprot.org/citations/21654840 | http://purl.uniprot.org/core/author | "Caspers P."xsd:string |
| http://purl.uniprot.org/citations/21654840 | http://purl.uniprot.org/core/author | "Takahara H."xsd:string |
| http://purl.uniprot.org/citations/21654840 | http://purl.uniprot.org/core/author | "Takahara H."xsd:string |
| http://purl.uniprot.org/citations/21654840 | http://purl.uniprot.org/core/author | "Vandenabeele P."xsd:string |
| http://purl.uniprot.org/citations/21654840 | http://purl.uniprot.org/core/author | "Vandenabeele P."xsd:string |
| http://purl.uniprot.org/citations/21654840 | http://purl.uniprot.org/core/author | "Lippens S."xsd:string |
| http://purl.uniprot.org/citations/21654840 | http://purl.uniprot.org/core/author | "Lippens S."xsd:string |
| http://purl.uniprot.org/citations/21654840 | http://purl.uniprot.org/core/author | "Declercq W."xsd:string |
| http://purl.uniprot.org/citations/21654840 | http://purl.uniprot.org/core/author | "Declercq W."xsd:string |
| http://purl.uniprot.org/citations/21654840 | http://purl.uniprot.org/core/author | "Roelandt R."xsd:string |
| http://purl.uniprot.org/citations/21654840 | http://purl.uniprot.org/core/author | "Roelandt R."xsd:string |
| http://purl.uniprot.org/citations/21654840 | http://purl.uniprot.org/core/author | "Gilbert B."xsd:string |
| http://purl.uniprot.org/citations/21654840 | http://purl.uniprot.org/core/author | "Gilbert B."xsd:string |
| http://purl.uniprot.org/citations/21654840 | http://purl.uniprot.org/core/author | "Denecker G."xsd:string |
| http://purl.uniprot.org/citations/21654840 | http://purl.uniprot.org/core/author | "Denecker G."xsd:string |