| http://purl.uniprot.org/citations/21659603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21659603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21659603 | http://www.w3.org/2000/01/rdf-schema#comment | "The DNA damage response (DDR) is brought about by a protein kinase cascade that orchestrates DNA repair through transcriptional and posttranslational mechanisms. Cell cycle arrest is a hallmark of the DDR. We screened for cells that lacked damage-induced cell cycle arrest and uncovered a critical role for Fanconi anemia and homologous recombination proteins in ATR (ataxia telangiectasia and Rad3-related) signaling. Three DDR candidates, the RNA processing protein INTS7, the circadian transcription factor CLOCK, and a previously uncharacterized protein RHINO, were recruited to sites of DNA damage. RHINO independently bound the Rad9-Rad1-Hus1 complex (9-1-1) and the ATR activator TopBP1. RHINO was recruited to sites of DNA damage by the 9-1-1 complex to promote Chk1 activation. We suggest that RHINO functions together with the 9-1-1 complex and TopBP1 to fully activate ATR."xsd:string |
| http://purl.uniprot.org/citations/21659603 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1203430"xsd:string |
| http://purl.uniprot.org/citations/21659603 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1203430"xsd:string |
| http://purl.uniprot.org/citations/21659603 | http://purl.uniprot.org/core/author | "Elledge S.J."xsd:string |
| http://purl.uniprot.org/citations/21659603 | http://purl.uniprot.org/core/author | "Elledge S.J."xsd:string |
| http://purl.uniprot.org/citations/21659603 | http://purl.uniprot.org/core/author | "McDonald E.R. III"xsd:string |
| http://purl.uniprot.org/citations/21659603 | http://purl.uniprot.org/core/author | "McDonald E.R. III"xsd:string |
| http://purl.uniprot.org/citations/21659603 | http://purl.uniprot.org/core/author | "Sowa M.E."xsd:string |
| http://purl.uniprot.org/citations/21659603 | http://purl.uniprot.org/core/author | "Sowa M.E."xsd:string |
| http://purl.uniprot.org/citations/21659603 | http://purl.uniprot.org/core/author | "Hurov K."xsd:string |
| http://purl.uniprot.org/citations/21659603 | http://purl.uniprot.org/core/author | "Hurov K."xsd:string |
| http://purl.uniprot.org/citations/21659603 | http://purl.uniprot.org/core/author | "Harper J.W."xsd:string |
| http://purl.uniprot.org/citations/21659603 | http://purl.uniprot.org/core/author | "Harper J.W."xsd:string |
| http://purl.uniprot.org/citations/21659603 | http://purl.uniprot.org/core/author | "Cotta-Ramusino C."xsd:string |
| http://purl.uniprot.org/citations/21659603 | http://purl.uniprot.org/core/author | "Cotta-Ramusino C."xsd:string |
| http://purl.uniprot.org/citations/21659603 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21659603 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21659603 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/21659603 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/21659603 | http://purl.uniprot.org/core/pages | "1313-1317"xsd:string |
| http://purl.uniprot.org/citations/21659603 | http://purl.uniprot.org/core/pages | "1313-1317"xsd:string |
| http://purl.uniprot.org/citations/21659603 | http://purl.uniprot.org/core/title | "A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling."xsd:string |
| http://purl.uniprot.org/citations/21659603 | http://purl.uniprot.org/core/title | "A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling."xsd:string |