| http://purl.uniprot.org/citations/21670212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21670212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21670212 | http://www.w3.org/2000/01/rdf-schema#comment | "The induction of neurite outgrowth and arborization is critical for developmental and regenerative processes. In this paper, we report that the BTB-kelch protein KLHL20 promoted neurite outgrowth and arborization in hippocampal and cortical neurons through its interaction with Cullin3 to form a ubiquitin ligase complex. This complex targeted PDZ-Rho guanine nucleotide exchange factor (RhoGEF), a protein abundantly expressed in the brain, for ubiquitin-dependent proteolysis, thereby restricting RhoA activity and facilitating growth cone spreading and neurite outgrowth. Importantly, targeting PDZ-RhoGEF to KLHL20 required PDZ-RhoGEF phosphorylation by p38 mitogen-activated protein kinase. In response to p38-activating neurotrophins, such as brain-derived neurotrophic factor and neurotrophin-3, KLHL20-mediated PDZ-RhoGEF destruction was potentiated, leading to neurotrophin-induced neurite outgrowth. Our study identified a ubiquitin-dependent pathway that targets PDZ-RhoGEF destruction to facilitate neurite outgrowth and indicates a key role of this pathway in neurotrophin-induced neuronal morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/21670212 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201103015"xsd:string |
| http://purl.uniprot.org/citations/21670212 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201103015"xsd:string |
| http://purl.uniprot.org/citations/21670212 | http://purl.uniprot.org/core/author | "Lin Y.M."xsd:string |
| http://purl.uniprot.org/citations/21670212 | http://purl.uniprot.org/core/author | "Lin Y.M."xsd:string |
| http://purl.uniprot.org/citations/21670212 | http://purl.uniprot.org/core/author | "Lin M.Y."xsd:string |
| http://purl.uniprot.org/citations/21670212 | http://purl.uniprot.org/core/author | "Lin M.Y."xsd:string |
| http://purl.uniprot.org/citations/21670212 | http://purl.uniprot.org/core/author | "Chen R.H."xsd:string |
| http://purl.uniprot.org/citations/21670212 | http://purl.uniprot.org/core/author | "Chen R.H."xsd:string |
| http://purl.uniprot.org/citations/21670212 | http://purl.uniprot.org/core/author | "Chuang H.H."xsd:string |
| http://purl.uniprot.org/citations/21670212 | http://purl.uniprot.org/core/author | "Chuang H.H."xsd:string |
| http://purl.uniprot.org/citations/21670212 | http://purl.uniprot.org/core/author | "Kao T.C."xsd:string |
| http://purl.uniprot.org/citations/21670212 | http://purl.uniprot.org/core/author | "Kao T.C."xsd:string |
| http://purl.uniprot.org/citations/21670212 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21670212 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21670212 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/21670212 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/21670212 | http://purl.uniprot.org/core/pages | "985-994"xsd:string |
| http://purl.uniprot.org/citations/21670212 | http://purl.uniprot.org/core/pages | "985-994"xsd:string |
| http://purl.uniprot.org/citations/21670212 | http://purl.uniprot.org/core/title | "PDZ-RhoGEF ubiquitination by Cullin3-KLHL20 controls neurotrophin-induced neurite outgrowth."xsd:string |
| http://purl.uniprot.org/citations/21670212 | http://purl.uniprot.org/core/title | "PDZ-RhoGEF ubiquitination by Cullin3-KLHL20 controls neurotrophin-induced neurite outgrowth."xsd:string |
| http://purl.uniprot.org/citations/21670212 | http://purl.uniprot.org/core/volume | "193"xsd:string |
| http://purl.uniprot.org/citations/21670212 | http://purl.uniprot.org/core/volume | "193"xsd:string |